week 3 haematology Flashcards
ideal place to take a bone marrow sample in an adult
posterior iliac crest
most appropriate technique to assign cell lineage
immunophenotyping
simple function of platelets
primary haemostasis
megakaryocytes
platelet precursor
polypoid
reticulocytes
immediate red cell precursor
myelocytes
nucleated precursor between neutrophils
name the developmental events in haemopoiesis
self renewal
proliferation
differentiation
maturation
apoptosis
first site of erythroid activity in fetus
yolk sac
- stops by week 10
bone marrow vasculature
venous sinuses:
- nutrient artery and periosteal network
- arterioles drain into sinuses- wide venous vessels, which open into larger central sinuses
how are mature cells released from the marrow
pass through fenestrations in endothelial cells to enter circulation
- associated with sinusoidal dilatation and increased blood flow
red marrow
haemopoietically active
yellow marrow
fatty and inactive
myeloid:erythroid ratio
relationship of neutrophils and precursors to proportion of nucleated red cells precursors
what regulates haemopoiesis
intrinsic properties of cells
signals from immediate surroundings and the periphery
specific anatomical area for optimal developmental signals
how do we assess haemopoiesis for non-lympoid mature cells
blood count, cell indices, morphology
less common- bone marrow examination
