presentations

Question 1

anaemia with raised LDH and raised bilirubin

Answer 1

haemolytic anaemia

Question 2

presence of spherocytes

Answer 2

extravascular haemolysis

Question 3

increased APTT, normal PT and bleeding time

Answer 3

haemophilia

Question 4

increased APTT and bleeding time, normal PT

Answer 4

von Willebrand’s disease

Question 5

presentation of TTP

Answer 5

fever, neuro signs and thrombocytopenia
haemolytic anaemia and renal failure

Question 6

most common inherited thrombophilia

Answer 6

factor V leiden

Question 7

what is factor V leiden

Answer 7

caused by mutation in factor V leading to activated protein C resistance

Question 8

hyposplenism blood film

Answer 8

target cells
howell-jolly bodies

Question 9

normocytic anaemia with low serum iron, low TIBC but raised ferritin

Answer 9

anaemia of chronic disease

Question 10

pathophysiological process of anaemia of chronic disease

Answer 10

reduced iron release from marrow
inadequate secretion of EPO
reduced red cell survival

Question 11

presentation of TRALI

Answer 11

hypotension

Question 12

presentation of chronic myeloid leukaemia

Answer 12

anaemia
weight loss and sweating
splenomegaly
granulocytes at different stages of maturation
decreased leukocyte ALP
aged 60+ usually

Question 13

most common form of leukaemia in adults

Answer 13

chronic lymphocytic leukaemia