Eradication and Vaccines Flashcards
1
Q
Rinderpest
A
2
Q
Types of polio vaccine
A
Must be trivalent for all 3 serotypes
3
Q
Salk vaccine
A
1955
inactivated virus w formaldehyde (crosslinks RNA to capsid)
4
Q
Sabin vaccine
A
1963
attenuated virus - no longer virulent
Given orally - sugar cube
5
Q
The cutter incident
A
260 children paralysed by vaccine
Vaccine virus hadn’t been properly inactivated
6
Q
How did Sabin attenuate PV?
A
Multiple passages through tissue culture
Virus became non-virulent due to loss of selection pressure on virulent genes
Mutations in 5’ UTR + capsid gene impaired translation and capsid assembly
7
Q
Salk vaccine disadvantages
A
May carry live virus
cost
no intestinal immunity
8
Q
Sabin vaccine disadvantages
A
virus shed in stools up to 3 months after
reversion to WT virulence possible
