Nephritic Diseases

Question 1

What often causes a Nephritic Syndrome picture?

Answer 1

Glomerulonephritis
– inflammation of glomerulus

Question 2

State how a Nephritic syndrome will present

Answer 2

PHAROH
- Proteinuria – MILD
- Hematuria
- Azotemia
- RBC casts
- Oliguria
- HTN

Question 3

State how a Nephritic Syndrome will present

Answer 3

PHAROH
- Proteinuria – MILD
- Hematuria
- Azotemia
- RBC casts
- Oliguria
- HTN

Question 4

What 3 findings are really shared between Nephritic and Nephrotic Syndrome?

Answer 4

Proteinuria
HTN
EDEMA

Question 5

Initial evaluation for Nephritic/Nephrotic syndrome presentations?

Answer 5

UA +/- Renal Biopsy

Question 6

What usually causes Post-infectious Glomerulonephritis?

Answer 6

Group A beta hemolytic Streptococcus Pyogenes infection

Question 7

What 2 antibodies may be present with Post-Infectious Glomerulonephritis?

Answer 7

ASO
Anti-DNase

Question 8

What will the level of C3 be with Post-Infectious Glomerulonephritis?

Answer 8

LOW C3!

Question 9

How will the immunofluorescence look with Post-Infectious Glomerulonephritis?

Answer 9

Lumpy-Bumpy

Question 10

What is the treatment for Post-infectious Glomerulonephritis?

Answer 10

Supportive; diuretics if fluid overloaded

Question 11

How may IgA Nephropathy present?

Answer 11

Concurrent URI/GI infection + Nephritic signs

Question 12

If a patient has Nephritic signs + URI/GI infection, what is the likely cause?

Answer 12

IgA Nephropathy

Question 13

What will the level of C3 be with IgA Nephropathy?

Answer 13

NORMAL C3

Question 14

What will be seen on immunofluorescence with IgA Nephropathy?

Answer 14

IgA deposits

Question 15

What vasculitis disease presents with IgA nephropathy?

Answer 15

Henoch-Schonlein Purpura

Question 16

What are the symptoms of Henoch-Schonlein Purpura?

Answer 16

IgA nephropathy – Nephritic signs
Palpable purpura
Arthralgias
Abdominal pain

Question 17

What are the symptoms of Henoch-Schonlein Purpura?

Answer 17

IgA Nephropathy – Nephritic signs
Palpable purpura
Arthralgias
Abdominal pain

Question 18

QUICK! What is affected with Granulomatosis with Polyangiitis?

Answer 18

Kidney
Lung
Sinus

Question 19

How may Granulomatosis with Polyangiitis present?

Answer 19

Nephritic syndrome – Hematuria/HTN
Hemoptysis
Sinus symptoms

Question 20

(+) C-ANCA or PR3-ANCA correlates to?

Answer 20

Granulomatosis with Polyangiitis

Question 21

QUICK! What is affected with Microscopic Polangiitis?

Answer 21

Kidney
Lung

Question 22

How may Microscopic Polangiitis present?

Answer 22

Nephritic syndrome – Hematuria/HTN
Hemoptysis

Question 23

(+) P-ANCA or MPO-ANCA correlates with?

Answer 23

Microscopic Polyangiitis

Question 24

QUICK! What is affected with Churg-Strauss Syndrome?

Answer 24

Kidney
Asthma

Question 25

How may Churg-Strauss Syndrome present?

Answer 25

Nephritic syndrome – Hematuria/HTN
Asthma
Other non-specific signs

Question 26

What cell type may be elevated with Churg-Strauss Syndrome?

Answer 26

Eosinophils
IgE

Question 27

With Granulomatosis with Polyangiitis, Microscopic Polangiiits and Churg-Strauss Syndrome, what will be seen on light microscopy?

Answer 27

Crescents

Question 28

What is Goodpasture syndrome?

Answer 28

Anti-GBM antibodies that causes rapidly progressive pulmonary hemorrhage and renal glomerulonephritis

Question 29

How will Goodpasture Syndrome present?

Answer 29

• Hemoptysis, respiratory distress
• Nephritic syndrome – Hematuria, AKI, HTN

Question 30

What will be seen on immunofluorescence with Goodpasture Syndrome?

Answer 30

LINEAR Anti-GBM deposits