Nephrotic Diseases Flashcards
What is often to blame for Nephrotic syndrome?
Systemic diseases
– Ex. DM, SLE, Amyloidosis
State the features of Nephrotic Syndrome
- Proteinuria (>3.5g/day)
- Hypoalbuminemia
- Hyperlipidemia (accelerated atherosclerosis)
- Hypercoagulable state
State the features of Nephrotic Syndrome
- Proteinuria (>3.5g/day)
- Hypoalbuminemia
- Hyperlipidemia
- Hypercoagulable state
Again, what features are shared between Nephrotic and Nephritic syndromes?
Proteinuria – more severe with Nephrotic
EDEMA
HTN
Nephrotic syndrome can present with Hyperlipidemia. What does this cause?
Accelerated atherosclerosis
Nephrotic Syndrome can present with a DVT or Renal V. Thrombosis. WHY?
Losing Antithrombin 3/Protein C or S in the urine which creates a hypercoagulable state
Patients with Nephrotic Syndrome are at risk for what? Why?
Infections – losing immunoglobulins in the urine too
What is the initial diagnostics for Nephrotic syndromes?
UA +/- Renal biopsy
What specific thing may be seen on UA with a Nephrotic syndrome and why?
Maltese crosses – LIPIDS (hyperlipidemia)
What is the most common cause of Nephrotic Syndrome in a kid?
Minimal Change Disease
How will Minimal Change Disease present?
Sudden onset Edema in a KID
What will be seen on light microscopy with Minimal Change Disease?
Effacement of epithelial foot processes
What is the treatment for Minimal Change Disease?
Steroids
List 4 Nephrotic syndrome causes
Minimal change disease
Focal Segmental Glomerulosclerosis
Membranous Nephropathy
Diabetic Nephropathy
List 4 Nephrotic syndrome causes
Minimal change disease
Focal Segmental Glomerulosclerosis
Membranous Nephropathy
Diabetic Nephropathy
