PARS CRUMB and SCRIBBLE Flashcards
how many PDZ complexes are there
3
where does PDZ bind to
COOH terminal of a protein
and to lipids
What does PDZ(1) do
binds Par3 to Par6
What does PDZ (2) do
Allows Par3 to bind to an array of Phosphoionisitdes
what does PDZ (3) do
binds PIP3 phosphate to PTEN
CRUMBS
what is the crumbs complex composed of
CRUMBS and 2 associated scaffold protein complexes
What is CRUMBS important for
localisation of complex, and other proteins to the region of adherens and tight junctions
SCRIBBLE
what is the scribble complex made up of
Scribble Glg and Lgl(scaffold prteins)
where were the scribble complexes found and how
through genetic screening in drosophila embryos
what is Scribble important for
important for apical/basolateral axis formation
what is scribble important for
maintanence ….
maintenance of polarity and beta catenin
what citing if this info from
Benedict Tan et al. (June 2020)
