302 Histopathology of the GI tract

Question 1

Describe the architecture of the intestine

Answer 1

Outside to inwards

-Serosa
-inner circular and outer longitudinal muscularis layer
-Submucosa
-Mucosa
-Lumen

Question 2

How does acute colitis occur histologically?

Answer 2

Not server changes because the disease process hasn’t lasted ling enough to cause too much damage

There will be inflammation

Question 3

what are some differentials for acute collitis?

Answer 3

Acute infection
Drugs
Early stage inflammatory disease

Question 4

What is the histology of chronic colitis?

Answer 4

-Distortion of architecture
-Hyperplasia of cells
-Ulcer-associated lineage indicating attempt to repair
-Fibrosis

Question 5

Differentials for chronic colitis

Answer 5

-Inflammatory bowel disease
drugs
-Microscopic colitis
-Diverticular colitis
-Some infections like syphilis and

Question 6

What are the features of active ulcerative colitis histologically?

Answer 6

-Inflammation in confined to the mucosa
-There will be signs of damage like abscesses and inflammation

Question 7

How does Crohn’s disease appear histologically?

Answer 7

-Cobble stone appearance
-Has areas of normal bowel (patchy skip lesions)
-Fibrosis
-Affects full thickness of the bowel
-Distortion of architecture
-Active inflammation
-Cryptitis and abscesses
-Granulomas (not present in UC)

Question 8

What is indeterminate colitis?

Answer 8

When the features histologically overlap that no diagnosis can be made

Relies heavily on history and clinical presentations