AML

Question 1

C

Question 2

C

Question 3

V

Question 4

blood investigation for AML ?

Answer 4

neutropenia: whilst white cell counts may be very high, functioning neutrophil levels may be low leading to frequent infections etc

thrombocytopenia: bleeding

Question 5

Clinical features of AML?

Answer 5

anaemia: pallor, lethargy, weakness

splenomegaly

bone pain

Question 6

What are the poor prognostic factors in AML?

Answer 6

Cytogenetic -
deletions of chromosome 5 or 7 = POOR PROGNOSIS

Age > 60 years

> 20% blasts after first course of chemo

Question 7

Acute promyelocytic leukaemia M3 presentation

Answer 7

DIC or thrombocytopenia often at presentation

Question 8

Diagnostic feature of AM3 - Acute promyelocytic leukaemia M3

Answer 8

Auer rods (seen with myeloperoxidase stain)

Question 9

Acute promyelocytic leukaemia M3
associated with what translocation ?

Answer 9

t(15;17)

Question 10

Acute promyelocytic leukaemia M3?

Answer 10

presents younger than other types of AML (average = 25 years old)

Question 11

does Acute promyelocytic leukaemia M3 have good prognosis ?

Answer 11

yes

Question 12

diagnosis of aml ?

Answer 12

8;21