Lymphocyte Development and Diversity

Question 1

What do cloned lymphocytes have in common?

Answer 1

They will have the same antigen receptor with the same antigen specificity

Question 2

What is clonal selection and clonal expansion?

Answer 2

A lymphocyte receptor will bind to a specific antigen (clonal selection). This causes signals that cause the cell to proliferate (clonal expansion)

Question 3

What is special about HsC

Answer 3

Hemapoetic stem cells make a copy of themselves and a pre-cursor new cell when they divide

Question 4

What is a CLP (common lymphoid progenitor cells)?

Answer 4

cell right after HsC that becomes T cells, B cells and NK cells.

Question 5

Where do B cells develop?

Answer 5

mostly develop in the bone marrow. The mature B cells will leave and go into the lymphoid tissue

Question 6

Where do T cells develop?

Answer 6

start in the bone marrow until they are Pro-T cells and then they will travel to the thymus. When the become Cd4 or Cd8 this is when they travel to the secondary lymphoid tissue.

Question 7

can B cells and antibodies see any type of microbe?

Answer 7

Yes

Question 8

Do T cells “see” extracellular microbes?

Answer 8

NO. They require a billboard protein (MHC/HLA) to recognize the peptide from a virus and then will bind to the actual infected cell displaying this billboard protein.

Question 9

Explain VDJ recombination math

Answer 9

(A+B) x C

Question 10

What creates the large repritoir of lymphocyte receptors?

Answer 10

combinational and junctional diversity in the variable region of antibodies or T-cell receptors

Question 11

What is a megakaryocyte

Answer 11

the pre-cursor to platelets