ID Flashcards

1
Q

Chancroid: cause?

A

Haemophilus ducreyi

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2
Q

Chancroid: Clinical presentation

A

Painful
Shallow, friable, nonindurated with ragged margins, granulomatous base, yellow or gray, necrotic purlent exudate

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3
Q

Chancroid: associated symptoms

A

Painful inguinal adenopathy called “buboes” present

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4
Q

Chancroid: diagnosis

A

Culture of lesion. not widely available)
CDC criteria for diagnosis:
1. >1 painful genital ulcer
2. No evidence of syphilis on dark-field or serologic test performed 7 days after onset of ulcer
3. Typical clinical presentation
4. Negative HSV test of ulcer

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5
Q

Lymphogranuloma venereum: Cause?

A

L1 L2 or L3 forms fo C. trchomatis

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6
Q

Lymphogranulmoa venerum: Clinical presentation?

A

Painless ulcer, small pustule at site of inoculation, can disappear rapidly

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7
Q

lymphogranuloma venereum: Associated symptoms

A

First stage: small, painless ulcer
Second stage: constitutional illness, painful lymphadenopathy, “groove” sign pathognomonic
Third stage: proctocolitis

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8
Q

Lymphogranuloma venereum: Diagnosis

A

Genital lesion swab lymph node aspirate tested using nucleic acid amplification tests

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9
Q

Granuloma inguinale: cause?

A

Klebsiella granulomatis

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10
Q

Granuloma inguinale: clinical presentation?

A

Painless, slowly progressive ulcerative lesion on genitals or perineum; bleeds easily on contact

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11
Q

Grauloma inguinale: associated symptoms

A

Regional lymphaenopahty is uncommon

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12
Q

Granuloma inguinale: diagnosis

A

Identification of Donovan bodies within histiocytes of granulation tissue smears or biopsy specimens

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13
Q

Syphilis: cause/

A

Treponema pallidum

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14
Q

Syphilis: clinical presentation

A

Painless ulcer with indurated hard, raised border and “punched-out” appearance

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15
Q

Syphilis associated symptoms

A

regional lymphadenopathy may occur

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16
Q

Syphilis: diagnosis

A

Screen: nontreponemal tests (RPR, VDRL)
Confirm: treponemal tests (FTA-ABS or TPPA)
Dark-field microscopy showing spirochetes

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17
Q

Genital herpes: cause?

A

HSV1 or HSV2

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18
Q

Genital herpes clinical presentation

A

Painful vesicular lesions developing into ulcer

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19
Q

genital herpes associated symptoms

A

Constitutional symptoms present in primary infection

20
Q

Genital herpes diagnosis

A

Viral culture or PCR for HSV DNA (from lesion)

21
Q

Chlamydia trachomatis: recommended regimens?

A

Azithromycin 1g orally once
or
doxycycline 100 mg orally twice daily for 7 days

22
Q

Chlamydia trachomatis: alternative regimens and special consierations?

A

Pregnancy:
azithromycin 1g orally once
Alternative regimens:
Erythromycin base 500 mg orally four times a day for 7 days
or
Erythromycin ethylsuccinate 800mg orally four times a day for 7days
or
levofloxacin 500 mg orally once daily for 7 days
or ofloxacin 300mg orally twice a day for 7 days

23
Q

Neisseria gonorrhoeae (cervix, urethra, and rectum): Recommended regimens?

A

Ceftriaxone 250 mg IM in a isngle dose
or
single-dose injectable cephalosporin
plus
azithromycin 1g orally once

24
Q

Neisseria gonorrhoeae (cervix, urethra, and rectum): alternative regimens and special considerations

A

Alternative if unable to offer IM: cefixime 400 mg orally in a single dose
plus
azithromycin 1 orally once
If azithromycin is not available or if patient is allergic to azithromycin, doxycycline 100 mg orally twice daily for 7 days may be substituted for azithromycin as the second antimicrobial
Severe cephalosporin allergy: contact infectious disease specialist

25
Q

N. gonorrhoeae (pharynx): Recommended regimens

A

Ceftriaxone 250 mg IM in a single dose
plus
azithromycin 1g orally once

26
Q

N. gonorrhoeae (pharynx): alternative regimens and special considerations

A

No alternative therapy available
Patients treated with an alternative regimen should return 14 days after treatment for a test of cure using either culture or NAAT. If the NAAT is positive, every effort should be made to perform a confirmatory culture.

27
Q

Treponema pallidum (primary and secondary syphilis or early latent syphilis, i.e, infection <12 months): Recommended regimens?

A

Benzathine penicillin G 2.4 million units IM in 1 dose

28
Q

Treponema pallidum (primary and secondary syphilis or early latent syphilis, i.e, infection <12 months): alternative regimens and special considerations

A

Penicillin allergy: doxycycline 100 mg orally twice daily for 14 days. Limited data suggest ceftriaxone 1-2g daily either IM or V for 10-14 days

29
Q

Treponema pallidum (late latent syphilis or syphilis of unknown duration): recommended regimens

A

Benzathine penicillin G 7.2 million units total, administered as three doses of 2.4 million units IM each at 1-week intervals

30
Q

Treponema pallidum (late latent syphilis or syphilis of unknown duration): alternative regimens and special considerations?

A

Penicillin allergy: doxycycline 100 mg orally twice daily for 28 days with close serologic and clinical follow-up

31
Q

Haemophilus ducreyi (chancroid: genital ulcers, lymphadenopathy): recommended regimens

A

Azithromycin 1g orally in a single dose
or
ceftriaxone 250 mg IM in single dose
or
ciprofloxacin 500 mg orally twice a day for 3 days
or
erythromycin base 500 mg orally 3 times a day for 7 days

32
Q

Haemophilus ducreyi (chancroid: genital ulcers, lymphadenopathy): Alternative regimens and special considerations?

A

NA

33
Q

C. trachomatis serovars L1, L2 or L3 (lymphogranuloma venereum): Recommended regimens?

A

Doxycycline 100 mg orally twice daily for 21 days

34
Q

C. trachomatis serovars L1, L2 or L3 (lymphogranuloma venereum): alternative regimens and special considerations

A

Alternative: erythromycin base 500 mg orally four times a day for 21 days
or
azithromycin 1g orally once a week for 3 weeks

35
Q

Bacterial vaginosis: Organism?

A

Replacement of normal vaginal flora (Lactobacillus sp) with anaerobes

36
Q

Bacterial vaginosis: type of organism?

A

Bacteria

37
Q

Bacterial vaginosis: discharge?

A

thin, gray-white, foul-smelling; adheres to vaginal walls

38
Q

Bacterial vaginosis: diagnostic features?

A

“Clue cells” on wet prep, vaginal pH > 4.5, + whiff test (KOH reveals “fishy odor”)

39
Q

Trichomoniasis: organism?

A

Trichomonas vaginalis

40
Q

Trichomoniasis: Type of organism?

A

protozoan

41
Q

Trichomoniasis: discharge?

A

Green-yellow, malodorous, frothy

42
Q

Trichomoniasis: diagnosti features

A

Motile trichomonads on wet mount, culture, PCR; can alsocause ervicitis with red, punctuate “strawberry” cervix

43
Q

Vulvovaginal candidiasis organism?

A

Candida

44
Q

Vulvovaginal candidiasis: type of organism?

A

Fungus (yeast)

45
Q

Vulvovaginal candidiasis: discharge?

A

White “cottage cheese” discharge

46
Q

Vulvovaginal candidiasis: diagnostic features

A

Fungal elements on wet prep, vaginal pH <4.5

47
Q
A