1. Introductory topics Flashcards
blood volume
10-12 pints or 6 liters
plasma, ———–—for coagulation factor deficiencies
plasma, cryoprecipitate—for coagulation factor deficiencies
apheresis
collection of only certain portions of blood from a donor
discovered ABO groups
Carl Landsteiner
goal of BB
to provide safe and effective transfusions to patients
Chromosome
a structure within a nucleus that contains a single strand of DNA
Homozygous
Heterozygous
inheritance of same/different allele from each parent
Dosage effect
serologic differences between a homozygous person and a heterozygous person
Gene
a single unit of genetic information, which codes for a protein
Allele
one of 2+ different forms of a gene at a specific locus
Locus
the specific site of a gene along the chromosome
Dominant
expressed phenotypically when homozygous or heterozygous
Recessive
only expressed phenotypically when homozygous
Codominant
both alleles are expressed phenotypically
Linkage
the association between distinct genes that occupy closely situated loci along a chromosome
inherited as a group (haplotypes)
Allelic gene interaction; position effect
interaction of two genes positioned cis or trans to one another (same chromosome or opposite chromosome)
Example of position effect
weak D in trans position to C gene