4. Blood groups II

Question 1

GPA and GPB are used by —- for invasion

Answer 1

Plasmodium falciparum

Question 2

S+ is more common in ——–
s+ is more common in ———

Answer 2

white people
Black people

Question 3

anti-M lectin

Answer 3

Iberis amara

Question 4

anti-N lectin

Answer 4

Bauhinia variegata

Question 5

generally IgM, but 50-80% has IgG component

Answer 5

anti-M/N

Question 6

pH dependent, most active around 6.5

Answer 6

anti-M

Question 7

natural antibodies

Answer 7

M & N
P
Lua

Question 8

enzymes increase activity

Answer 8

Kidd
P

Question 9

enzymes no change

Answer 9

Kell
U

Question 10

enzymes decrease activity

Answer 10

Duffy (except anti-Fy:3 and anti-Fy:5)
M, N

Question 11

variable response to enzymes

Answer 11

Ss
Lutheran

Question 12

associated with malaria resistance

Answer 12

Fy(a=b=)

Question 13

fades in vivo and in vitro

Answer 13

Kidd

Question 14

GPA and GPB tend to be inherited together as a….

Answer 14

haplotype

Question 15

marked dosage

Answer 15

anti-M
anti-N

Question 16

7 main Kell alleles

Answer 16

K (Kell) & k (Cellano)
Kpa (Penney) & Kpb (Rautenberg)
Jsa (Sutter) & Jsb (Matthews)
KO (very rare, no known antithetical allele)

Question 17

most common Kell phenotype

Answer 17

K=k+, Kp(a=b+), Js(a=b+)

Question 18

————- (4) treatment inactivates Kell antigens

Answer 18

AET, 2-ME, DTT, and ZZAP

Question 19

suppresses erythropoiesis in baby

Answer 19

anti-K

Question 20

main duffy alleles (8)

Answer 20

Fya and Fyb (clinically significant)
Fy:3 (clinically significant)
Fy:4
Fy:5
Fy:6
Fyx (variation of Fyb)
Fy (null phenotype)

Question 21

syntetic with Rh genes

Answer 21

Duffy

Question 22

rare and found only in Asians/Polynesians
screen using…

Answer 22

Jk(a=b=) AKA Jk:-3
2M urea

Question 23

definitive delayed extravascular HTR

Answer 23

anti-Jka

Question 24

2 reasons for Jk(a=b=)

Answer 24

Homozygous Jk genotype

Inheritance of a dominant suppressor gene In(Jk)

Question 25

P and P1 develop from a common….

Answer 25

lactosylceramide

Question 26

P is ——- from —-; P1 is from ———- (type 2 precursor)

Answer 26

globoside from Pk
paragloboside

Question 27

Common autoantibody reactive at room temp and reacting best at 4°

Answer 27

Anti-I

Question 28

Often made by patients with Mycoplasma pneumoniae infections

Answer 28

Anti-I

Question 29

Patients with infectious mono often have transient but potent….

Answer 29

anti-i

Question 30

P2 phenotype only more common in…

Answer 30

Asians

Question 31

examples of low freqs

Answer 31

CW, Rhb (Rh system)
Jsa, Kpa (Kell system)
Lua

Question 32

Can be autoadsorbed using C4 coated RBCs

Answer 32

Chido/Rodgers antigens

Question 33

IgG with low affinity

Answer 33

Chido/Rodgers antibodies

Question 34

HLA destroyed by…

Answer 34

chloroquine

Question 35

AHG reactions are seldom reproducible

Answer 35

HLA/BG

Question 36

Bga

Answer 36

B-7

Question 37

Bgb

Answer 37

B-17

Question 38

Bgc

Answer 38

A-28

Question 39

MNS clinical significance

Answer 39

MN – rare HTR and HDFN
SsU – delayed HTR; severe HDFN

Question 40

BG stands for…

Answer 40

Bennett-Goodspeed

Question 41

Lutheran clinical significance

Answer 41

Lua – none
Lub – mild delayed HTR and HDFN

both involved in sickle cell crises

Question 42

Kell clinical significance

Answer 42

HTR (most common cause after ABO/Rh)
HDFN, but rare
anti-K suppresses erythropoiesis

McLeod + CGM

Question 43

Duffy clinical significance

Answer 43

Fya, Fyb, and Fy:3 only
acute or delayed HTR
mild HDFN
anti-Fy:3 reacts with all RBCs except Fy(a=b=)

Question 44

Kidd clinical significance

Answer 44

anti-Jka definitive delayed extravascular HTR
mild, rare HDFN
binds complement very well