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Boards Prep > Pharmacology of Mood Disorders > Flashcards

Pharmacology of Mood Disorders Flashcards

1
Q

What is the neurotrophic hypothesis of mood disorders?

A

Decreased brain-derived neurotrophic factor (BDNF) causes dysregulation of neurogenesis and neuronal plasticity, thus leading to mood disorders.

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2
Q

What is the monoamine hypothesis of mood disorders?

A

Depression is related to the amount or function of serotonin, norepinephrine, and dopamine.

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3
Q

What is the neuroendocrine hypothesis of mood disorders?

A

Hormonal abnormalities (such as increased cortisol) causes decreased BDNF and thus depression

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4
Q

What are the subgroups of antidepressant medications?

A

SSRIs, SNRIs, TCAs, 5-HT antagonists, Heterocyclides, MAO inhibitors

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5
Q

What drugs belong to the SSRI class of antidepressants?

A

Citalopram, escitalopram, fluoxetine, paroxetine, fluvoxamine, sertraline

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6
Q

What antidepressant is indicated for treating major depressive disorder with cognitive impairment?

A

Vortioxetine

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7
Q

What are the SNRI antidepressants?

A

Duloxetine, venlafaxime

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8
Q

What are the TCA antidepressants?

A

Amitriptiline, clomipramine, imipramine

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9
Q

What antidepressants are 5-HT antagonists?

A

Nefazodone, trazodone

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10
Q

What are the heterocyclic antidepressants?

A

Amoxapine, bupropion, mirtazapine, maprotiline

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11
Q

This antidepressant is also approved for smoking cessation.

A

Bupropion

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12
Q

What classes of antidepressants are considered “atypical antidepressants?”

A

5-HT antagonists, heterocyclics

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13
Q

What antidepressants are MAO inhibitors?

A

Phenelzine, selegiline, tranylcypromine

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14
Q

These classes of antidepressants have relatively high protein binding.

A

SSRIs, TCAs, 5-HT antagonists, MAO inhibitors

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15
Q

What antidepressant medication is indicated for the treatment of neuropathic pain and fibromyalgia?

A

SNRIs - Duloxetine, venlafaxime

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16
Q

What class of antidepressants should only be used for MDD resistant to other treatments?

A

MAO inhibitors

17
Q

What ADRs are associated with TCAs?

A

Coma, convulsions, cardiotoxicity

18
Q

What ADRs are associated with SSRIs?

A

Nausea, headache, anxiety, agitation, insomnia, sexual dysfunction, serotonin syndrome

19
Q

How is Lithium excreted from the body?

A

Unconjugated by the kidney

20
Q

These drugs decrease renal clearance of lithium and increase risk of toxicity.

A

Thiazides, NSAIDs

21
Q

What is the use of Lithium in the treatment of mood disorders?

A

Prophylaxis for mood stabilization in patients with bipolar disorder

22
Q

What is the MOA of Lithium?

A

Suppresses IP3 & DAG signaling

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