small group disease list

Question 1

local inflammation nerve pinch localized reduction of conduction velocity)

Answer 1

tennis elbow

Question 2

autoimmune disease with antibodies to peripheral myelin and global reduction
of conduction velocity in peripheral nerves

Answer 2

Guillain–Barré syndrome

Question 3

autoimmune disease with antibodies to CNS myelin and global reduction of
conduction velocity in CNS

Answer 3

Multiple Sclerosis

Question 4

loss of alpha motor neurons, decrease of the size of
compound action potential

Answer 4

Amyotrophic lateral Sclerosis/ Poliomyelitis

Question 5

lack of relative refractory period, lower AP threshold. Can be caused by 2-AP poison
induced block of Voltage gated K channels

Answer 5

Hyperexcitability

Question 6

autoimmune disease with antibodies to nicotinic AChR at the NMJ. Reduction of
Safety factor via reduction of mepp amplitude and quantal size

Answer 6

Myasthenia Gravis

Question 7

autoimmune disease with antibodies to presynaptic P type calcium channels
at the NMJ. Reduction of Safety factor via reduction of vesicle release and quantal content

Answer 7

Lambert Eaton Myasthenia

Question 8

lack of lactate production during anaerobic exercise Genetic defect with lack of
myophosphorylase in White Type II skeletal muscle. Damage to Type I via production of free oxygen
radicals)

Answer 8

McArdle disease:

Question 9

caused by constant depolarization of pancreatic beta cells ATP sensitive Potassium
channel or L type voltage gated Ca2+ channels

Answer 9

Hyperinulinism

Question 10

rationale for the use of sulfonylurea that blocks ATP sensitive K+ channel of pancreatic
beta cells as first therapy)

Answer 10

Diabetes Type 2