mixed action sympathomimetics

Question 1

what are the mixed action sympathomimetics drugs?

Answer 1

ephedrine
mephentermine

Question 2

what do mixed action sympathomimetics do?

Answer 2

mimic epi/norepi and stimulate adrenergic receptor directly and prevent degradation of the neurotransmitters
this is why they’re called mixed action

Question 3

what is the mechanism of ephedrine?

Answer 3

adrenergic alpha and beta receptors agonist and inhibiting reuptake. increasing release of norepi from vesicles in nerve cells
this will increase HR, BP and bronchodilation

Question 4

clinical indication of ephedrine?

Answer 4

tx of hypotension under anesthesia
allergic conditions like bronchial asthma

Question 5

mechanism of mephentermine?

Answer 5

alpha adrenergic agonist
acts indirectly by releasing endo norepi
increase cardiac output and systolic and diastolic pressures

Question 6

clinical indication for mephentermine?

Answer 6

maintain BP in hypotensive states