indirect sympathomimetics Flashcards
what are the indirect sympathomimetic drugs?
amphetamine-like
modafinil
armodafinil
what do indirect sympathomimetic drugs treat?
ADHD
what is the mechanism of indirect sympathomimetics?
compete with NET to prevent the reuptake of norepi thereby increasing the conc at the synaptic cleft
what are modafinil and armodafinil?
they’re amphetamine substitute with less side effects
clinical indication for modafinil and armodafinil?
narcolepsy - increase norepi to keep alert
adhd
what are the two catecholamine reuptake inhibitors?
atomoxetine
cocaine
mechanism of catecholamine reuptake inhibitors?
inhibits reuptake of norepi transporter NET
what kind of drug is cocaine?
a stimulant
what is the pharmacodynamic of atomoxetine?
increase norepi in the synapses
what is the pharmacodynamic of cocaine?
inhibit dopamine reuptake in the pleasure center of the brain which will increase the dopamine effect