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biol1203 > UNIT 5 - RESPIRATORY SYSTEM > Flashcards

UNIT 5 - RESPIRATORY SYSTEM Flashcards

1
Q

Respiratory system

A

Group of organs and tissues used for gas exchange (breathing)

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2
Q

Main respiratory structures (8)

A
  • Nasal cavity (nose
  • Mouth
  • Pharynx (throat)
  • Larynx (voice box)
  • Trachea (windpipe)
  • Bronchi (large airways)
  • Bronchioles (small airways)
  • Lungs
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3
Q

Nasal cavity

A

Provides airway for respiration and moistens/warms the entering air. Filtering of air by hairs the mucous (lysozyme) and contains olfactory receptors

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4
Q

Pharynx

A

Common passageway for air from nasal and buccal cavity to trachea

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5
Q

Larynx

A

Common path for food and air to separate controlled by swallow reflex and epiglottis. Also the voice box

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6
Q

Epiglottis

A

Flap of cartilage that protects the glottis, opening to the trachea

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7
Q

Trachea

A

Long U shape tube connecting larynx to lungs supported by cartilage rings to put air into and out of the lungs

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8
Q

Thyroid cartilage

A

2 large plates of cartilage on anterior wall of larynx (adams apple)

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9
Q

Bronchi

A

Two primary bronchi branch into secondary and tertiary bronchi and takes air into lungs from trachea

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10
Q

Right primary bronchus

A

Serves the right lung

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11
Q

Left primary bronchus

A

Serves the left lung

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12
Q

Bronchioles

A

Further divisions of the tertiary bronchi, the air passage inside the lungs

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13
Q

Branching of bronchial tree in order (9)

A
  • Trachea
  • Primary bronchi
  • Secondary bronchi
  • Bronchioles
  • Terminal bronchioles
  • Respiratory bronchioles
  • Alveolar duct
  • Alveolar sac
  • Alveoli
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14
Q

Alveoli

A

Air sacs at the end of bronchioles made of a single layer of squamous epithelial cells surrounded by capillaries where gas exchange occurs and accounts for most of the lungs volume with the largest surface area

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15
Q

How many alveoli do we have

A

300 million

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16
Q

Alveolar epithelial cells (3)

A
  • Forms nearly continuous lining
  • Flat shape
  • Main site of gas exchange
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17
Q

Other characteristics of alveolar cells (3)

A
  • Free surfaces contain microvilli secreting surfactant
  • Reduce tendency to collapse
  • Macrophages
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18
Q

Breathing

A

Process of getting oxygen into lungs and carbon dioxide out of the lungs

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19
Q

Thoracic cavity

A

Sealed cavity that houses the lungs and the heart

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20
Q

Rib cage

A

Surrounds the lungs for protection

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21
Q

Diaphragm

A

Muscle that helps to inhale and exhale and separates the lungs from the abdomen

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22
Q

Lungs

A

Major organ in chest to transport oxygen and remove carbon dioxide surrounded by two membranes (pleural membranes)

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23
Q

2 types of pleural membranes:

A
  • Parietal pleura (outer): attached to walls of thoracic cavity and lines inner surface
  • Visceral pleura (inner): Covers the lungs
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24
Q

Pleural cavity

A

Fluid filled space between pleural membranes for lubrication between lung & wall of chest cavity, and to hold the two membranes together ensuring lungs don’t collapse

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25
Q

Inspiration (inhalation)

A

Process of taking air into lungs, breathing in

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26
Q

Expiration (Exhalation)

A

Process of removing air from lungs, breathing out

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27
Q

Inhalation process (4)

A
  • Air sucked in lung
  • Diaphragm contracts and move down
  • External intercostal muscles contract and ribs move upward & outward
  • Volume of chest cavity increases, decreasing pressure to -1mm Hg in lungs until 0 (atmospheric pressure)
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28
Q

Exhalation process (4)

A
  • Air is forced out lungs
  • Diaphragm relaxes and moves up
  • External intercostals relax and ribs move downward & inward
  • Volume of chest cavity decreases, increasing pressure to +1mm Hg in lungs until intrapulmonary pressure is 0
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29
Q

Relaxed exhalation

A

Muscle relaxation

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30
Q

Forced exhalation

A

Muscle relaxation and contraction of internal intercostal and abdominal muscles to increase thoracic pressure, aiding in the rapid expulsion of air from the lungs

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31
Q

What mechanism controls breathing

A

Autonomic nervous system (involuntary), however we can control the rate and depth of breathing

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32
Q

Breathing control center

A

AKA pons and medulla oblongata (also the cardiac centers)

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33
Q

Relationship between breathing control center and cardiac center

A

The more the heart beats, the more breathing occurs. This is because as the heart beats faster, it uses more energy and sends more oxygen to body

34
Q

Medulla general function

A

Sends signals to muscles that control respiration

35
Q

Medulla (inspiratory center)

A

Accounts for normal inspiration by sending impulses to inspiratory muscles every few seconds and also activates during exercise

36
Q

Medulla (expiratory center)

A

Expiration is typically passive due to relaxation of unstimulated inspiratory muscles, but during exercise it stimulates expiratory muscles to cause forceful exhalation

37
Q

Pons general function

A

Control rate or speed of respiration

38
Q

Pons (pneumotaxic area)

A

Limits duration of inspiration and increases inspiration rate by sending inhibitory impulses to inspiratory area to prevent lungs from overfilling (eg. Exercise)

39
Q

Pons (apneustic area)

A

Increases duration of inspiration and decreases inspiration rate by sending inhibitory impulses to the inspiratory area to lengthen the inspiratory period (eg. Occurs when oxygen levels are lower than normal

40
Q

Hering-Breuer (inflation) reflex

A

Keeps the lungs from overinflating with inspired air

41
Q

Process of inflation reflex (3)

A
  • Forced inspiration stimulates stretch receptors in lining of lung and sends signals to brain
  • Signals inhibit inspiratory area and apneustic area
  • Inspiration stops and passive expiration occurs
42
Q

Breathing control centers

A

Receives incoming information from pons/medulla and information gets interpreted, integrated and if required, response is initiated

43
Q

Efferent PNS (control of breathing)

A

Sends a response initiated by breathing control centers to respiratory muscles (intercostal/diaphragm)

44
Q

Respiratory muscles (control of breathing)

A

Respond to message from efferent PNS to increase or decrease rate/depth of breathing

45
Q

Sensory receptors:

A

Located in major arteries to measure O2 and CO2 concentrations

46
Q

Afferent PNS

A

Sends information of O2 and CO2 concentrations to the breathing control center

47
Q

Chemoreceptors

A

Special nerve/receptor that sense changes in chemical composition of blood

48
Q

2 important chemoreceptors

A
  • Central chemoreceptors
  • Peripheral chemoreceptors
49
Q

Central chemoreceptors

A

Located in the medulla and respond to changes in H+ and CO2 concentrations in CSF

50
Q

Peripheral chemoreceptors

A

Located in aortic bodies (aortic arch) and carotid bodies (end of common carotid) and responds to changes in H+, CO2 and O2 concentrations in blood

51
Q

Mechanism for normal blood concentrations levels

A

Via negative feedback loop

52
Q

Negative feedback control for blood concentration (5)

A
  • Stimulus: Some stimulus disrupts homeostasis (Increase in arterial blood PCO2 or decrease in pH/PO2)
  • Receptor: Receives stimulus by central chemoreceptors in medulla or peripheral chemoreceptors in aortic and carotid bodies send signal to inspiratory area in medulla oblongata
  • Effector: Muscles of inhalation and exhalation contract more forcefully and frequently (hyperventilation)
  • Cause decrease in arterial blood PCO2, increase in pH and PO2
  • Repeat
53
Q

Tidal volume

A

The volume breathed in or out at rest (300-500ml)

54
Q

Expiratory reserve volume

A

The maximum volume of air that can be forced out after normal exhalation (1000-1500ml)

55
Q

Inspiratory reserve volume

A

The maximum volume of air that can be inhaled after a normal inhalation

56
Q

Vital capacity

A

Maximum volume of air that can be exhaled after maximum inhalation (2800-5000ml)

57
Q

Residual volume

A

Volume of air remaining in lung after maximum exhalation

58
Q

Total lung capacity

A

Total volume of air that lungs are capable of holding

59
Q

Dead air space

A

Air that never enters the alveoli but remains in the air passageways (150ml)

60
Q

How is oxygen transported into the blood

A

Almost all of O2 (approx. 98%) is carried by an iron containing protein found inside RBC (hemoglobin) and becomes oxyhemoglobin. Each hemoglobin molecule carries 4 O2, 1 RBC contains 300 million hemoglobin = 1200 million O2 molecules per RBC

61
Q

How does oxygen get from the blood to the cell

A

O2 enters blood by diffusion and is transported as oxyhemoglobin via circulatory system to capillaries. In the capillaries, O2 is released from hemoglobin and enters cells by diffusion

62
Q

How does the CO2 get from the cell to the lungs

A

Approx. 23% of CO2 combines with hemoglobin (carbaminohemoglobin) and CO2 produced by cell enter blood stream via diffusion (7% CO2 dissolved in plasma). The CO2 reacts with H2) to form bicarbonate and leaves blood by diffusion = 1 hemoglobin can only carry 1 CO2 molecule

63
Q

How much of O2 and CO2 transported by hemoglobin

A

O2 98.5%, CO2 23%

64
Q

How much of O2 and CO2 get transported by getting dissolved in plasma

A

O2 1.5% CO2 7%

65
Q

How much of O2 and CO2 transport as bicarbonate

A

O2 N/A, CO2 70%

66
Q

Euponoea

A

Normal breathing

67
Q

Dyspnoea

A

Difficult breathing (asthma, bronchitis, emphysema)

68
Q

Tachypnoea

A

Fast breathing (anxiety, fever in children)

69
Q

Hyperpnoea

A

Deep breathing (exercise, high altitudes)

70
Q

Aponea

A

Lack of breathing (drugs, trauma)

71
Q

Hyperventilation

A

Increased rate or depth of breathing

72
Q

Causes of hyperventilation (2)

A
  • Respiratory causes: Asthma, emphysema
  • Non respiratory causes: Exercise, fever, hyperthyroidism, anxiety (all increased metabolism)
73
Q

Consequences of hyperventilation (2)

A
  • Hypocapnia (decrease CO2 levels) = alkalosis (increase pH level) = brain dysfunction such as tingling, unconsciousness
  • Hypocapnia (decrease CO2 levels = vasodilation = hypotension (lower bp)
74
Q

Hypoxia

A

Reduced oxygen supply to body tissues

75
Q

Internal causes of hypoxia (functional deficit in body systems) (7):

A
  • Hemoglobin deficiencies: Anemia, carbon monoxide poisoning
  • Arterial obstruction
  • Hypotension
  • Edema: Congestive heart failure, renal failure
  • Congenital defects: Septal defect, patent ductus arteriosus
  • Obstruction of airways: Asthma, bronchitis
  • Diffusion deficiency in lungs: Emphysema, pneumonia, pulmonary edema
76
Q

External causes of hypoxia (low oxygen levels in environment) (3)

A
  • High altitudes
  • Overcrowded rooms
  • Diving
77
Q

Physiological consequences of hypoxia (3):

A
  • Cyanosis
  • Tachycardia
  • Dizziness
78
Q

Cyanosis

A

Blueish skin color due to accumulation of non oxygenated blood

79
Q

Tachycardia

A

Autonomic nervous system mediated increase in heart rate

80
Q

Dizziness

A

Caused by insufficient oxygen supply to brain

biol1203 (12 decks)

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