Campbell - Geriatric

Question 1

Physiologic Changes

• ___ total body water
• ___ lean body mass
• ___ body fat
• ___ baroreceptor response/activity
• ___ heart rate variability
• ___ hepatic blood flow
• ___ renal blood flow
• ___ neurotransmitter volume (sensitivity to CNS adverse effects)

Question 2

PK Changes with Aging

• generally no change in ___ of most drugs (but ___ Tmax)
• ___ Vd and ___ [ ] of water soluble drugs like ___
• ___ Vd and ___ T1/2 of lipid soluble drugs like ___
• ___ clearance and ___ T1/2 of most hepatically cleared drugs like ___
• ___ clearance and ___ T1/2 of most renally-cleared drugs like ___

Question 3

Medications and Risk of Falls (6)

Answer 3

1. sedative/hypnotics
2. neuroleptics/antipsychotics
3. antidepressants
4. opiods
5. loop diuretics
6. alpha blockers