Enzyme inhibition Flashcards
how does enzyme inhibition occur
when inhibitors bind to the enzyme
what do inhibitors do
they stop/ reduce a reaction
how will a small concentration of a inhibitor effect the rate of reaction
it will reduce the reaction
how will a excess concentration of a inhibitor effect the rate of reaction
it will prevent the reaction completely
what are the two types of inhibitor
competitive
non competitive
how does a competitive inhibitor work
it has a similar structure to the active site of the enzyme
this makes it able to make a physical barrier that prevents the formation of the enzymes substrate complex
how does a non competitive inhibitor work
they bind to a separate part of the enzyme.
it then interacts with the chemicals in the enzyme and these are transferred throughout the enzyme causing it to change shape slightly. therefore the enzyme is not complimentary to its substrate.
what is the separate part of the enzyme called (non competitive)
allosteric site
what is another type of inhibition
end product inhibition
what is end product inhibition
what is it an example of
cell only wants just enough of the product eg not to less. not to much.
its an example of negative feedback
what happens if the concentration of the final product is to high
the product acts back on itself
it goes back to the first stage enzyme inhibits enzyme so it stops the process happening so it stops being made
what happens in the concentration of the final product is to low
the enzyme becomes reactivated therefore the process starts again
what are the differences between competitive and non competitive inhibitors
competitive
makes a physical block
less powerful
mostly revsible
non competitive
creates chemical changes
powerful inhibitation
binds permantly
