hepatitis Flashcards
ssRNA viral hepatitis
Hep A
Hep C
Hep C
Hep D
Hep E
fecal- oral transmission viral Hepatitis
Hep A
Hep E
blood borne and or sexual transmission viral Hepatitis
Hep B
Hep C
Hep D
dsDNA viral hepatitis
Hep B
acute viral hepatitis
Hepatitis A
Hep E
hep b
chronic viral hepatitis
Hep B,C ,E
oncogenic hepatitis
HEP B
Hep C
Child turcotte-pugh score
compensated
Class A: 5-6 points (least severe)
decompensated
Class B: 7-9 points (moderately severe disease)
Class C: 10-15 points ( most severe)
compensated cirrhosis
asymptomatic with or without gastro-esophageal varices
decompensated
Jaundice
ascites
variceal hemmorage
hepatic encephalopathy
HAV transmission
ingestion of fecal matter, even microscropic amounts of
- close person to person contact w infected person
-sexual contact
-ingestion of contaminated food or drinks
HAV treatment
supportive care only
pre exposure prevention HAV
<6 months & healthy
-immune globulin
6-11months & healthy
-HAV vaccine
> 12month - 40 yo
-HAV vaccine
> 40 yo & healthy
-immune globulin + vaccine
> 6mo ,immunocompromised or liver disease
-immune globulin + vaccine
> 6 mon, vaccine CI or declined
-immune globulin
post exposure propylaxis
<12 mo & healthy
-immune globulin
> 12 mo- 40 yo + healthy
-HAV vaccine
> 40 yo & healthy
-immune globulin
> 12 mo & immunocompromised or chronic liver disease
-HAV vaccine +immune globulin
> 12 mo& vaccine CI or declined
-immune glubulin
HAV routine prevention
Prevention
-regular hand washing w soap
-avoid contaminated water/ ice, fresh produce, uncooked foods
vaccination
- HAV only (Havrix, Vaqta
—- 2 dose series: 1 shot at 0 & 6 mo
—>12 months
-HAV + HBV (twinrix)
—>18yo only
clinical presentation of HAV
-fever, fatigue, loss of appetite, N??V, ab pain, dark urine, clay color stool, jaudice
-iceteric sclera skin, mild weight loss.hepatomegaly
- positive serum IgM anti-HAv, elevation of serum bilirubin and hepatic transaminase