Penicillins

Question 1

Penicillin G (benzylpenicillin)

IV

Answer 1

Pfizerpen

IV

Question 2

Penicilin G procaine

IM

Answer 2

Wycillin

IM

Question 3

Penicillin G benzathine

IM

Answer 3

Bicillin L-A
IM

Question 4

Penicillin G procaine and benzathine

Answer 4

Bicillin C-R

Question 5

Penicillin VK ( phenoxymethyl penicillin)

PO

Answer 5

Pen-vee K, Veetids

PO

Question 6

MOA of Penicillin

Answer 6

inhibit cell wall synthesis by binging to penicillin binding protein

Question 7

Elimination of penicillin

Answer 7

renal

Question 8

Side effects of penicillin

Answer 8

PCN allergy
seizures
GI

procaine formula:
dizziness, palpitations,
auditory or visual disturbances,
fear of impending death resolves within 15-30 mins

Question 9

Pregnancy category of Penicillin

Answer 9

B

Question 10

PCN G (IV, IM, SC)

Answer 10

susceptible to break down in gastric acid
IV= severe or complicated infections
IM= cleared rapidly from the body

Question 11

Spectrum activity of Penicillin

Answer 11

good activity against no b-lactamase producing gram positive and gram negative, limited gram negative activity

Question 12

Gram Positive of Penicillins

Answer 12

Streptococcus A (S. pyogenes)
Streptococcus B (s. agalactiae)
Streptococcus C,F, and G

Streptococcus pneumoniae
Streptococcus virdans group

Entercoccus app

Bacillius spp.
Corynebacterium spp

Question 13

gram neg of Penicillins

Answer 13

Neisseria meningitidis

pasturella multacida

Question 14

anaerobes for penicillin

Answer 14

Closteridium spp. (exclude c. difficile)

peptostreptoccus spp.

cutibacterium spp.

Question 15

spirochetes of penicillin

Answer 15

treponema palladium

Leptospira interrogans

Question 16

penicillins have no staph (T/F)

Answer 16

True

Question 17

Penicillin is mostly (GN/GP)

Answer 17

GP

Question 18

Penicillin is bactericidal or bacteriostatic

Answer 18

bactericidal

Question 19

Penillicinase-resistant (aka antistaptylcoccal) penicillins purpose

Answer 19

the emergence of penicillinase producing stapylococci spp.

Question 20

examples of Penillicinase-resistant (aka antistaptylcoccal) penicillins

Answer 20

oxacillin, nafcillin, dicloxacillin

Question 21

oxacillin (IV)

Answer 21

bactocill

Question 22

nafcillin (IV)

Answer 22

Unipen, nafcil

Question 23

dicloxacillin (PO)

Answer 23

dynapen, diclocil, dycill

Question 24

Spectrum of activity for Penillicinase-resistant (aka antistaptylcoccal) penicillins

Answer 24

Penicillinase-producing strains of staph
Methicillin susceptible s.aureus (MSSA)
Methicillin susceptible s. epidermidis (MSSE)
Virdidans group streptococcus spp
s.pneumonie PCN susceptible strains
LESS STEPT compared to penicillin

Question 25

Penillicinase-resistant (aka antistaptylcoccal) penicillin DOES NOT have activity against

Answer 25

MRSA MRSE enterococcus spp. gram negative

Question 26

elimination of Penillicinase-resistant (aka antistaptylcoccal) penicillin

Answer 26

biliary and hepatic

Question 27

DDI of Penillicinase-resistant (aka antistaptylcoccal) penicillin

Answer 27

induce warfarin metabolism

Question 28

SE of Penillicinase-resistant (aka antistaptylcoccal) penicillin

Answer 28

PCN allergy cholestatic hepatitis interstitial nephritis N/V/D

Question 29

Pregnancy category of Penillicinase-resistant (aka antistaptylcoccal) penicillin

Answer 29

B

Question 30

Purpose of aminopenicillins

Answer 30

developed to extend coverage to include non-beta lactamase producing negative organisms

Question 31

examples of aminopenicillins

Answer 31

ampicillin , amoxicillin

Question 32

ampicillin (IV, PO)

Answer 32

Principen

Question 33

Amoxicillin

Answer 33

Amoxil, Trimox, Moxilin

Question 34

Spectrum of activity of aminopenicilin

Answer 34

similar to natural penicillins with: improved enteroccoccus spp activity less activity of s. progenies, s.agalactiae, s. pneumonia improved GN coverage NO STAPH

Question 35

gram pos of aminopenicillins

Answer 35

Streptococcus A (S. pyogenes) Streptococcus B (s. agalactiae) Streptococcus C,F, and G Streptococcus pneumoniae Streptococcus virdans group Entercoccus app Bacillius spp. Corynebacterium spp Listeria monocytogenes ( added)

Question 36

gram neg of aminopenicillins

Answer 36

Cocci n. meningitidis (Amp) moraxella catarrhalis Rod p. multocida e.coli proteus mirabilis h.influenzae shigella spp (amp) salmonella spp. (amox)

Question 37

anaerobes of aminopenicillins

Answer 37

Closteridium spp. (exclude c. difficile) peptostreptoccus spp. cutibacterium spp.

Question 38

elimination of aminopenicllins

Answer 38

renal

Question 39

SE of aminopenicillins

Answer 39

PCN allergy GI (N/V/D)

Question 40

Pregnancy category of aminopenicillin

Answer 40

B

Question 41

B-tactams/ Blactamase inhibitors (BL/BLI) purpose

Answer 41

to overcome the resistance due to beta lactamase producing bacteria

Question 42

amoxicillin/ clavulanic acid (PO)

Answer 42

augmentin

Question 43

ampicillin/ sulbactam (IV)

Answer 43

Unasyn

Question 44

piperacillin/ tazobactam (IV)

Answer 44

zosyn

Question 45

sulbactam/ durlobactam (IV)

Answer 45

xacduro

Question 46

spectrum of activity of ampicillin/ sulbactam and amoxicillin/ clavulanic acid

Answer 46

same as ampicillin and amoxicillin +beta lactamase producing strains of s.aureus, h. influenzae, m. catarrhalis, bacteroids spp., and Enterobacterales slightly better enterococcus spp.

Question 47

MOA of (BL/BLI)

Answer 47

b-lactamase inhibitor binds to beta-lactamase to prevent breakdown of the antibiotic

Question 48

SE of (BL/BLI)

Answer 48

PCN allergy N/V/D nephrotoxicity (increase risk w vanco) xacduro: abnormal LFTs, diarrhea, anemia, hypok

Question 49

Elimination of (BL/BLI)

Answer 49

renal

Question 50

Pregnancy category of BL/BLI

Answer 50

B