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ID > Penicillins > Flashcards

Penicillins Flashcards

1
Q

Penicillin G (benzylpenicillin)

IV

A

Pfizerpen

IV

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2
Q

Penicilin G procaine

IM

A

Wycillin

IM

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3
Q

Penicillin G benzathine

IM

A

Bicillin L-A
IM

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4
Q

Penicillin G procaine and benzathine

A

Bicillin C-R

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5
Q

Penicillin VK ( phenoxymethyl penicillin)

PO

A

Pen-vee K, Veetids

PO

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6
Q

MOA of Penicillin

A

inhibit cell wall synthesis by binging to penicillin binding protein

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7
Q

Elimination of penicillin

A

renal

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8
Q

Side effects of penicillin

A

PCN allergy
seizures
GI

procaine formula:
dizziness, palpitations,
auditory or visual disturbances,
fear of impending death resolves within 15-30 mins

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9
Q

Pregnancy category of Penicillin

A

B

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10
Q

PCN G (IV, IM, SC)

A

susceptible to break down in gastric acid
IV= severe or complicated infections
IM= cleared rapidly from the body

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11
Q

Spectrum activity of Penicillin

A

good activity against no b-lactamase producing gram positive and gram negative, limited gram negative activity

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12
Q

Gram Positive of Penicillins

A

Streptococcus A (S. pyogenes)
Streptococcus B (s. agalactiae)
Streptococcus C,F, and G

Streptococcus pneumoniae
Streptococcus virdans group

Entercoccus app

Bacillius spp.
Corynebacterium spp

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13
Q

gram neg of Penicillins

A

Neisseria meningitidis

pasturella multacida

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14
Q

anaerobes for penicillin

A

Closteridium spp. (exclude c. difficile)

peptostreptoccus spp.

cutibacterium spp.

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15
Q

spirochetes of penicillin

A

treponema palladium

Leptospira interrogans

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16
Q

penicillins have no staph (T/F)

A

True

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17
Q

Penicillin is mostly (GN/GP)

A

GP

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18
Q

Penicillin is bactericidal or bacteriostatic

A

bactericidal

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19
Q

Penillicinase-resistant (aka antistaptylcoccal) penicillins purpose

A

the emergence of penicillinase producing stapylococci spp.

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20
Q

examples of Penillicinase-resistant (aka antistaptylcoccal) penicillins

A

oxacillin, nafcillin, dicloxacillin

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21
Q

oxacillin (IV)

A

bactocill

22
Q

nafcillin (IV)

A

Unipen, nafcil

23
Q

dicloxacillin (PO)

A

dynapen, diclocil, dycill

24
Q

Spectrum of activity for Penillicinase-resistant (aka antistaptylcoccal) penicillins

A

Penicillinase-producing strains of staph
Methicillin susceptible s.aureus (MSSA)
Methicillin susceptible s. epidermidis (MSSE)
Virdidans group streptococcus spp
s.pneumonie PCN susceptible strains
LESS STEPT compared to penicillin

25
Q

Penillicinase-resistant (aka antistaptylcoccal) penicillin DOES NOT have activity against

A

MRSA
MRSE
enterococcus spp.
gram negative

26
Q

elimination of Penillicinase-resistant (aka antistaptylcoccal) penicillin

A

biliary and hepatic

27
Q

DDI of Penillicinase-resistant (aka antistaptylcoccal) penicillin

A

induce warfarin metabolism

28
Q

SE of Penillicinase-resistant (aka antistaptylcoccal) penicillin

A

PCN allergy
cholestatic hepatitis
interstitial nephritis
N/V/D

29
Q

Pregnancy category of Penillicinase-resistant (aka antistaptylcoccal) penicillin

A

B

30
Q

Purpose of aminopenicillins

A

developed to extend coverage to include non-beta lactamase producing negative organisms

31
Q

examples of aminopenicillins

A

ampicillin , amoxicillin

32
Q

ampicillin (IV, PO)

A

Principen

33
Q

Amoxicillin

A

Amoxil, Trimox, Moxilin

34
Q

Spectrum of activity of aminopenicilin

A

similar to natural penicillins with:
improved enteroccoccus spp activity
less activity of s. progenies, s.agalactiae, s. pneumonia
improved GN coverage
NO STAPH

35
Q

gram pos of aminopenicillins

A

Streptococcus A (S. pyogenes)
Streptococcus B (s. agalactiae)
Streptococcus C,F, and G

Streptococcus pneumoniae
Streptococcus virdans group

Entercoccus app

Bacillius spp.
Corynebacterium spp
Listeria monocytogenes ( added)

36
Q

gram neg of aminopenicillins

A

Cocci
n. meningitidis (Amp)
moraxella catarrhalis

Rod
p. multocida
e.coli
proteus mirabilis
h.influenzae
shigella spp (amp)
salmonella spp. (amox)

37
Q

anaerobes of aminopenicillins

A

Closteridium spp. (exclude c. difficile)

peptostreptoccus spp.

cutibacterium spp.

38
Q

elimination of aminopenicllins

A

renal

39
Q

SE of aminopenicillins

A

PCN allergy
GI (N/V/D)

40
Q

Pregnancy category of aminopenicillin

A

B

41
Q

B-tactams/ Blactamase inhibitors (BL/BLI) purpose

A

to overcome the resistance due to beta lactamase producing bacteria

42
Q

amoxicillin/ clavulanic acid (PO)

A

augmentin

43
Q

ampicillin/ sulbactam (IV)

A

Unasyn

44
Q

piperacillin/ tazobactam (IV)

A

zosyn

45
Q

sulbactam/ durlobactam (IV)

A

xacduro

46
Q

spectrum of activity of ampicillin/ sulbactam and amoxicillin/ clavulanic acid

A

same as ampicillin and amoxicillin

+beta lactamase producing strains of s.aureus, h. influenzae, m. catarrhalis, bacteroids spp., and Enterobacterales

slightly better enterococcus spp.

47
Q

MOA of (BL/BLI)

A

b-lactamase inhibitor binds to beta-lactamase to prevent breakdown of the antibiotic

48
Q

SE of (BL/BLI)

A

PCN allergy
N/V/D
nephrotoxicity (increase risk w vanco)
xacduro: abnormal LFTs, diarrhea, anemia, hypok

49
Q

Elimination of (BL/BLI)

A

renal

50
Q

Pregnancy category of BL/BLI

A

B

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