Periodontitis Flashcards

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1
Q

what are the host factors which influence the microflora

A

disease/antibiotics/OH
diet
salivary flow rate/pH
GCF
microbial interactions
gaseous environment

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2
Q

what host factors affect periodontitis risk

A

smoking
genetics
pregnancy
systemic disease
nutrition

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3
Q

what are the development phases of periodontitis biofilm

A

adhesion
colonisation
accumulation
complex community
dispersal

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4
Q

when does the biofilm become a problem

A

when it is not managed

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5
Q

what bacteria are present in health

A

actinomyces
fusobacterium

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6
Q

what bacteria are present in gingivitis

A

actinomyces
prevotella intermedia
bacteroides

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7
Q

what bacteria are present in periodontitis

A

porphyromonas gingivalis
taneralla forsythia
prevotella intermedia

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8
Q

what does p gingivalis need to attach

A

fusobacterium

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9
Q

what is the keystone pathogen for periodontitis

A

p gingivalis

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10
Q

what are the virulence factors of p gingivalis

A

host cell tissue adherence
elaboration of proteases
endotoxin - proinflammatory
capsular polysaccharide
tissue toxic metabolic byproducts

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11
Q

what part of the bacteria helps with adhesion

A

fimbrillar adhesions

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12
Q

what do gingipains do

A

provide peptides from haem
possess haemaglutinin
activate matrix metalloproteinases

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13
Q

how does p gingivalis manipulate host defences

A

biofilm lifestlye
gingipains - degrade innate receptors and cytokines
induction of MMPs
subversion

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14
Q

what is the other big bacteria involved in periodontitis

A

A. actinomycetemcomitans

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15
Q

what are the systemic implications of periodontal disease

A

increased CV disease
increased RA risk
increased diabetes risk

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16
Q

how do you clinically manage periodontitis

A

mechanical disruption
chemotherapeutic
probiotics
vaccines
surgery