Periodontitis Flashcards
what are the host factors which influence the microflora
disease/antibiotics/OH
diet
salivary flow rate/pH
GCF
microbial interactions
gaseous environment
what host factors affect periodontitis risk
smoking
genetics
pregnancy
systemic disease
nutrition
what are the development phases of periodontitis biofilm
adhesion
colonisation
accumulation
complex community
dispersal
when does the biofilm become a problem
when it is not managed
what bacteria are present in health
actinomyces
fusobacterium
what bacteria are present in gingivitis
actinomyces
prevotella intermedia
bacteroides
what bacteria are present in periodontitis
porphyromonas gingivalis
taneralla forsythia
prevotella intermedia
what does p gingivalis need to attach
fusobacterium
what is the keystone pathogen for periodontitis
p gingivalis
what are the virulence factors of p gingivalis
host cell tissue adherence
elaboration of proteases
endotoxin - proinflammatory
capsular polysaccharide
tissue toxic metabolic byproducts
what part of the bacteria helps with adhesion
fimbrillar adhesions
what do gingipains do
provide peptides from haem
possess haemaglutinin
activate matrix metalloproteinases
how does p gingivalis manipulate host defences
biofilm lifestlye
gingipains - degrade innate receptors and cytokines
induction of MMPs
subversion
what is the other big bacteria involved in periodontitis
A. actinomycetemcomitans
what are the systemic implications of periodontal disease
increased CV disease
increased RA risk
increased diabetes risk
