OFG Flashcards
OFG vs angio-oedema?
AO
- oedema of oral and facial soft tissues due to increase in fluid exudate from capillaries but with no lymphatic drainage obstruction
OFG
- no increase in exudate of fluid from capillaries
- obstruction to lymphatic drainage allowing fluid to accumulate within soft tissues
AO settles fast, OFG settles slowly
Histology of OFG vs AO
AO
- tissue swelling in connective tissue
OFG
- giant cell multinucleated granulomas within the tissue
- obstructing lymphatics
What type of hypersensitivity reaction is AO and OFG?
AO
- 1
OFG
- 3
Histological markers of OFG?
Granulomatomous infiltration and mild oedema
Prescience of giant cells that are multinucleated
Histological markers of Angio oedema?
Oedema
Leukocyte infiltration
Absence of epidermal changes
Sometimes mast cell degranulation
What must be ruled out when OFG / AO is suspected?
Sarcoidosis
Tuberculosis
Crohns
Ulcerative colitis
Give epidemiology of OFG
Can present at any age but common in later childhood / adolescents
Often low level presentation and mild
If patient presents with OFG, what is important to ask about general health?
Any abdominal pain or altered bowel habit? Could possibly be a crohns issue
Management of OFG?
Consider GI symptoms of crohns
- sequential growth monitoring
3 month dietary exclusion of things like benzoate or cinnamon
Topical tx for angular chelitis
- miconazole
Topical tx to lip or facial erythema
- tacrolimus ointment 0.03%
What foods often trigger OFG?
Bernzoic acid
Sorbic acid
Cinnamon products
Chocolate