OFG Flashcards

1
Q

OFG vs angio-oedema?

A

AO
- oedema of oral and facial soft tissues due to increase in fluid exudate from capillaries but with no lymphatic drainage obstruction

OFG
- no increase in exudate of fluid from capillaries
- obstruction to lymphatic drainage allowing fluid to accumulate within soft tissues

AO settles fast, OFG settles slowly

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2
Q

Histology of OFG vs AO

A

AO
- tissue swelling in connective tissue

OFG
- giant cell multinucleated granulomas within the tissue
- obstructing lymphatics

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3
Q

What type of hypersensitivity reaction is AO and OFG?

A

AO
- 1

OFG
- 3

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4
Q

Histological markers of OFG?

A

Granulomatomous infiltration and mild oedema

Prescience of giant cells that are multinucleated

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5
Q

Histological markers of Angio oedema?

A

Oedema

Leukocyte infiltration

Absence of epidermal changes

Sometimes mast cell degranulation

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6
Q

What must be ruled out when OFG / AO is suspected?

A

Sarcoidosis

Tuberculosis

Crohns

Ulcerative colitis

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7
Q

Give epidemiology of OFG

A

Can present at any age but common in later childhood / adolescents

Often low level presentation and mild

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8
Q

If patient presents with OFG, what is important to ask about general health?

A

Any abdominal pain or altered bowel habit? Could possibly be a crohns issue

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9
Q

Management of OFG?

A

Consider GI symptoms of crohns
- sequential growth monitoring

3 month dietary exclusion of things like benzoate or cinnamon

Topical tx for angular chelitis
- miconazole

Topical tx to lip or facial erythema
- tacrolimus ointment 0.03%

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10
Q

What foods often trigger OFG?

A

Bernzoic acid

Sorbic acid

Cinnamon products

Chocolate

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