Oral Viral Infections Flashcards
8 stages of HSV replication?
Bind to cell
Enter cell
Release nuclear acids
Nuclear entry into nucleus
Gene expression
DNS replication
Packaging of viral proteins
Egress
Appropriate tests for viral infection?
Viral swab
- flocked swab
- placed in molecular sample solution
Blood sample
- EDTA
Clinical features of HSV?
- gingivo stomatitis - along branch of trigeminal nerve and preceded by a prodrome period
- herpes labialis
- herpetic whitlow
- Bell’s palsy
- genital herpes
How test for HSV?
Vesicle / ulcer fluid - swab taken
- sent for PCR testing and molecular sample media
Clinical features of HZV?
Vesicles appear along dermatome where virus has been dormant
- more common in V1
Shingles
- rash / vesicles on one side of the head or face
- can have muscle weakness
- intensely painful sometimes with paraesthesia too
Complications with HZV?
Post herpetic neuralgia
- shooting pain along dermatome
Secondary bacterial infection
Opthalmic zoster
Why is it important to treat shingles early?
Reduces severity and duration of pain and complications
- pain can mimic toothache
Clinical features of hand foot and mouth disease?
Fever, runny nose, sneezing, cough
Skin rash on hands and feet
Mouth blisters
Body and muscle aches
Tx of hand foot and mouth disease?
No specific medical tx
- symptomatic relief
- prevent dehydration
- emphasise role of hand hygiene to avoid transmission
Signs and symptoms of measles?
High fever, cough, runny nose - 7-14 days after exposure
2-3 days later
- koplik spots on inside of mouth - tiny white dots
3-5 days later
- rash begins of face and spreads down
Clinical features of mumps?
Caused by what?
Caused by paramyxovirus family
Headaches and fever
- swelling of the parotid glands unilaterally or bilaterally
Organ inflammation elsewhere
MOA aciclovir?
Broken down into aciclovir triphopshate
This competes for integration into Viral DNA
- then acts as a chain terminator
Thus inhibiting viral DNA replication
