Regeneration and repair

Question 1

What is resolution?

Answer 1

• Something completely repairs
• Initiating factor removed
• Tissue undamaged or able to regenerate

Question 2

What is repair?

Answer 2

• Initiating factor still present
• Tissue damaged and unable to regenerate

Question 3

What organ can undergo resolution?

Answer 3

Liver

Question 4

Can the lung regenerate?

Answer 4

Pneumocytes can, alveolar walls cannot

Question 5

Does lobar pneumonia cause damage to lungs?

Answer 5

Yes but not to alveolar walls

Question 6

What type of skin wound is an abrasion?

Answer 6

Most superficial
Only top layer of epidermis damaged
Will heal

Question 7

What is healing by 1st intention?

Answer 7

• Edges of skin all together, no infection and heals
• Forms scar that’s red initially due to capillaries, then white due to collagen
  -Collagen makes stronger than surrounding skin

Question 8

What is healing by 2nd intention?

Answer 8

• Traumatic wounds, loss of skin
• Takes longer as blood vessels and skin has to grow
• Bigger scars

Question 9

What happens in repair?

Answer 9

• Replacement of damaged tissue by fibrous tissue
• Collagen produced by fibroblasts

Question 10

What are examples of repair?

Answer 10

• heart after myocardial infarction
• brain after cerebral infarction (fibrosis in brain called brain gliosis)
• spinal cord after trauma

Question 11

Which cells regenerate?

Answer 11

• hepatocytes
• pneumocytes
• all blood cells
• gut epithelium
• skin epithelium
• osteocytes

Question 12

Which cells don’t regenerate?

Answer 12

• myocardial cells
• neurones

Question 13

Will this be resolution or repair?
- Man aged 30 takes a large overdose paracetamol overdose and doesn’t
come to hospital for 2 days
- He spends a few days on ITU with liver failure but then recovers

Answer 13

RESOLUTION as not on going issue

Question 14

Will this be resolution or repair?
- A child aged 3 falls off a climbing frame onto his hand, he fractures his
clavicle
- He has his arm in a sling for 4 weeks and is very good about keeping it in the sling

Answer 14

RESOLUTION

Question 15

Will this be resolution or repair?
- A child aged 3 falls off a climbing frame onto his hand, he fractures his
clavicle
- He has his arm in a sling for 4 weeks but won’t keep the sling on
and moves his arm a lot

Answer 15

REPAIR
- Can only join together if ends of bone are immobilised