Pathology of ageing Flashcards
1
Q
What happens to telomeres with age?
A
Length decreases
2
Q
What is dermal elastosis?
A
Wrinkly skin
3
Q
What is dermal elastosis caused by?
A
- Protein cross linking
-Collagen in skin gives elasticity
-UVB light cross links strands of collagen, go rigid and wrinkly
4
Q
What does a lack of oestrogen cause in osteoporosis?
A
- Increased bone resorption
- Decreased bone formation
5
Q
How do cataracts form?
A
- Lens in eye made of crystalline protein
- When exposed to UVB light, cross links protein → becomes opaque
6
Q
Describe senile dementia
A
- Individual neurons dying, usually apoptosis
- Plaques
- Neurofibrillary tangles
7
Q
Describe sarcopenia
A
- Lack of muscle
- Decreased growth hormone
- Decreased testosterone
- Increased catabolic cytokines
8
Q
What is deafness caused by?
A
- Hair cells in cochlear don’t divide
- When damaged, lost
