genetic explanation of schizophrenia Flashcards
give an example of a second degree relative
aunt/uncle
if you have a second degree relative does the likliness of you having schizophrenia increase
yes
what does the likeliness increase by if you have a second degree relative
2-6%
if you have a first degree relative what does your likeliness increase by
6-17%
who argues about the role of twins in likeliness of schizophrenia
Gottesman
what is gottasmans arguement
that their is a bigger risk in mz twins compared to concordance rates of dz twins
what is the chance for a mz twin you could be diagnosed with schizophrenia
48%
what is the chance for a dz twin you could be diagnosed with schizophrenia
17%
what is anouther genetic explination for schizoprenia
common genes and rare copies
who found the evidance for common genes and rare copies
Tiwari et al
what vaiation does Tiwari argue can cause schizophrenia
Xq23
what is anouther expliantion of schizophrenia
22q11.2 deletion syndrome linked to schizophrenia
what are some supporting evidances for genetic expliantion of schizophrenia
gottesman
Tienari
negative gottesman
what did tenari find
looked at adoption studies- found that 10.3% of adopted children who had schizophrenic mother developed schizophrenia in adult hood compared to 1.1% of adopted children who did not have a schizophrenic mother.
t/f this increases the validity that gentic factors heavily influence schizophrenia
why can you critise both gottesman and tienari.
because their statistics do not show a 100%
gottesman only found a 48% concordance rate meaning that over half did of mz twins did not develope schizophrenia
tienari found only 10.3% which is a much smaller amount compared to around 90% who didn’t have a scizophrenic mother and still developed schizophrenia
