Structural Aberrations: Maker Chromosomes

Question 1

Some marker chromosomes are familial and have resulted from _____ arising in meiosis in a parent or ancestor.

Answer 1

Robertsonian translocation between satellite chromosomes (often involving the short arm of chromosome 15)

Question 2

T/F. Provided the marker chromosome (or centric fragment) contains only repetitive and ribosomal DNA, there will be no clinical con- sequences.

Answer 2

True.

Question 2

Cat-eye syndrome is due to

Answer 2

inv dup(22)

Question 2

What is the Prader–Willi syndrome/Angelman syndrome critical region?

Answer 2

inv dup(15)