autoimmune disorders Flashcards
1
Q
Normal immune response
A
- recognition phase: body recongizes something is not suppose to be there
- amplification phase: start fighting off the antigen
- effector phase: getting rid of antigen
- terminator phase: going back to normal
- memory
2
Q
Dysfunction of the immune system
A
- genetic alterations: mutations that inactivate receptors (immunodeficiencies)
- signaling molecules; conditions with inflammatory components
3
Q
T
types of autoimmune disease
A
- organ specific
- systemic
4
Q
organ specific autoimmune
A
- addisons disease
- chron disease
- diabetes
- graves disease
- affects a specific organ
5
Q
Systemic
autoimmune diseases
A
- Amyloidosis
- MS
- Myasthenia gravis
- psoriasis
- lupus
- affects the body
6
Q
Etiology ad risk factors for developing an autoimmune disease
A
- genetic
- hormonal
- enviromental influences
7
Q
Immunologic tolerance
what is it and types
A
- unresponsiveness of the immune system to it’s own tissue
- self tolerance
- central
- peripheral
8
Q
self tolerance (immunologic tolerance)
A
- The ability of the immune system to be unreactive to self/ones tissue
- therefore t-cells recognize and react against self antigens if this is lost
the immune system’s ability to recognize what is ‘self’
9
Q
Central immunologic tolerance
A
- loss of self reactive t cells and b cells
- produces immature lymphocytes
- lymphocytes that do not get survivial signals = apoptosis
10
Q
Peripheral immunologic tolerance
A
- mature lymphocytes recognition becomes inactive or supressed by T-cells
11
Q
Pathogenesis
of autoimmune disorders
A
- disruption of immunoregulatory mechanism
- change in cell mediated or humoral immune response
- results in self-destruction of tissues
12
Q
Gene susceptibility in autoimmune
A
- gene maping
- candidate for Loci for susceptibility: identifiable regions of a chromosome that are inherited with the illness in families,
- Epigenetic (internal/external factors)
- HLA locus
13
Q
Infections, tissue injury and autoimmunity
How are infections and tissue injury related to autoimmunity
A
- bacteria
- myocoplasma
- viruses
- can precipitate autoimmunity esp. if left untreated
- there is also a genetic component
14
Q
Medical management of autoimmune disorders
A
- DX: lab tests, and presentation
- Treatment: meds ie. corticosteriods, saliclates (apsirin), other
15
Q
Systemic lupus
A
- Discoid and SLE
- inflammatory disease
- more common in women of child bearing age
- african american more likely
- first degress relatives having it puts you at risk
