Immune-Mediated Polyarthritis Flashcards
Polyarthropathy:
What hypersensitivities are associated with IMPA? Antigens?
- Type III - immune complex deposition
- Type II - antigen deposition or autoantibody formation
haptens (drugs), microbes, diets, tumors, self-antigens
What are the 4 classification of idiopathic IMPA?
- uncomplicated***
- reactive - infectious/inflammatory
- enteropathic - GI or hepatic disease
- neoplastic - outside joints
What breeds have a predisposition for developing Type I IMPA?
(uncomplicated)
sporting or large breeds, 2-6 y/o - GSD, Labs, Dobermans, Spaniels, Retrievers, Terriers, Poodles
What are 5 causes of Type II IMPA?
(infectious/inflammatory)
- endocarditis
- diskospondylitis
- pyelonephritis
- panreatitis
- chronic infections
What breeds are predisposed to developing non-erosive IMPA? What signs are associated?
- JUVENILE ONSET of AKITAS: neck and back pain, lymphadenopathy, meningitis
- SHAR-PEI FEVER: swollen hocks, amyloidosis
What breed is prone to developing polyarthritis-myositis? What sign is most commonly seen?
Spaniels
myalgia and muscle swelling —> bilaterally symmetrical atrophy and muscle contracture
What 2 breeds are predisposed to developing polyarthritis-meningitis? What sign is most commonly seen?
- Bernese Mountain dogs
- Boxers
cervical spinal pain
What drugs and vaccines can cause non-erosive IMPA?
DRUGS - sulfas, penicillins, cephalosporins, phenobarbarbital (Dobermans)
VACCINE - canine distemper virus, feline calicivirus
What is systemic lupus erythematosus (SLE)?
form of IMPA - multisystem, immune-mediated disease common in younger (2-4 y/o) GSDs, Shetland Sheepdogs, Irish Setters, OESD, Cocker Spaniels, Collies, and Poodles
What are 7 major signs of SLE?
- polyarthritis
- glomerulonephritis
- hemolytic anemia
- thrombocytopenia
- leukopenia
- skin lesions
- myositis
What are 4 minor signs of SLE?
- fever
- oral ulcerations
- lymphadenopathy
- CNS signs
What is erosive polyarthritis?
idiopathic Rheumatoid-like polyarthritis caused by the production of antibodies directed against IgA or IgM, which complexes within joint and Abs against collagen
- middle-ages, small breeds
What are 6 causes septic arthritis?
- bacterial - Staph, Sterp, Mycoplasma, Pasteurella, L-form, Bartonella
- fungal - Blasto, Coccidio, Crypto
- viral - distemper, calicivirus
- Leishmania
- Lyme
- Anaplasma phagocytophilium, Ehrlichia ewingii, RMSF
(usually only one joint affected)
What pattern on septic arthritis is associated with bacteremia?
a few, large proximal joints - shoulder, hip, elbow, stifle
- infection demonstrated within joints +/- blood or urine