Lesson 4.6: HIV and its RNA Replication

Question 1

HIV was first discovered as a virus that infects ______ named _______-

Answer 1

chimpanzees
SIV, simian immunodeficiency virus

Question 2

Since HIV is an immunodeficiency virus it infects _______ that serves as a _______

Answer 2

T cells
protector of the immune system

Question 3

Patients with HIV has _____

Answer 3

defective immune response

Question 4

HIV can be transferred through

Answer 4

Body fluids

Question 5

HIV came from _____ in ______ which jumped to HIV late _______

Answer 5

chimpanzee
central africa
1800s

Question 6

What is the genome of HIV virus

Answer 6

RNA-RT to DNA

Question 7

Explain the Replication steps of an RNA virus
1. Attachement and penetration
2. Synthesis
3. Assemby
4 Release

Answer 7

1.
-virus bind to primary and coreceptor on the cell membrane, enzyme remoe viral protein coat
-RT transcribes viral RNA to ds DNA
-ds DNA incoporated in the HC genome

2. Synthesis
   -Viral genes are transcribed to RNA
   -RNA is packaged in viruses with some is translated to HIV proteins at the ribosomes

Assembly
-protein coats the viral RNA and ezymes, migrate to cell membrane

Release
-new viruses buds from the HC

Question 8

HIV particles interacts with ______ which is found in ________

Answer 8

protein CD4
white blood cells

Question 9

The interaction between the viral and host proteins determines the _______ of the virus

Answer 9

specificity

Question 10

HIV must produce a ______ of its ______ before incorporating genes into the ________

this is carried out by what enzyme

Answer 10

DNA copy
RNA
host’s DNA

Reverse transcriptase `