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Therapy: year 3 > Influenza, Herpes simplex and RSV > Flashcards

Influenza, Herpes simplex and RSV Flashcards

1
Q

What are the influenza virus types?

A

A, B, C, D

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2
Q

which virus types cause seasonla epidmeics in humans (flu season)?

A

a and B

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3
Q

Which viruses cause global pandemics (like the emergence of a new variant)

A

A

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4
Q

whihc viruses casue mild disease and ccnot be epidmic?

A

C

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5
Q

Whihc virus does not cause disease in humans

A

D

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6
Q

Strnad A subtypes (proteins on surface of virus)

A

A(H1N1)
A(H3N2)

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7
Q

What acts as antigens on the a strand?

A

H and N surface proteins

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8
Q

what is antigenic drift?

A

minor changes in the H and N antigens that cause antigenicity and mean that we virus is slightly different each time

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9
Q

What are the subtypes for the B virus?

A

Victoria and Yamagata

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10
Q

Whihc B strain is currenlty more widely circulating

A

Victoria

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11
Q

what strains do virsuses currently proetct againts

A

all A and B strians, reformulated every year to account for antigenic drift

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12
Q

Differences between cold and infkuenza

A

influenza more aburpt and dangerous

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13
Q

How is infection transmissted

A

viral sheeding and via inhalation

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14
Q

how long does influenza incubate

A

7 days

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15
Q

when is influenza infectious and who has longer infection children or aultd

A

infectious 1 prior to symtpotms till 5-7 after onset of symptoms

children 10 days

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16
Q

Vaccination for influenza what time of year? how long does it take to work?

A

sept- end, october

2 weeks to develop resistance

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17
Q

vax for influenza ages and dosing

A

6 months up normal dose

65 plus high dose

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18
Q

What are the influenza vax?

A

IIV
- IIV3
-IIV4

RIV
- RIV4

LAIV
-LAIV3
-LAIV4

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19
Q

whihc vax are made from hen eggs?

A

IIV and LAIV

20
Q

function of adjuvents?

A

boost immune response

21
Q

What vax is not delivered IM, how is it delivered?

A

LAIV - nasal spary

22
Q

infleunza vax serious and rare side effect

A

Oculo-repiratory syndrom ( red eyes bilateraly and one resp sym)

and guille barre syndrom

23
Q

Antiviral tx for influenza include whihc drugs?

A

Oseltamivir
Zanamivir
Peramivir
Baloxavir

24
Q

Drug formulations

A

Oseltamivir - po (tab or liquid)
Zanamivir - inhalation
Peramivir - IV
Baloxavir - po (one dose)

25
Q

Oseltamivir S/E

A

GI and CNS

26
Q

Zanamivir S/E

A

Gi and respiratory - can’t use for COPD or asthma

SJS/TEN and cardiac arrhythmias

27
Q

Peramivir S/E

A

GI and SJS/TEN, anayphalysis, hallucinations

28
Q

Baloxavir S/E

A

hyoersentivity rxn, hallucination

29
Q

Herpes simplex infections, types

A

HSV1 - cold sores
HSV2 - genitals

30
Q

Course of hSV infections

A

once infection travels from epthial cells to nerves cells and can lie dormant for many years

symptoms brought on by triggers

31
Q

HSV brekout/ outbreak

A

prodromal feeling 1-2 days befroe

can get flu-like symptoms

genital herpes may affect urination

Sym may be worst if immunocomprimised, HIV/AID or pot trasnplant

can spread to eyes

32
Q

Managment of HSV

A

relive symtpoms not sure disease

  • acyclovir, famcyclovir, valcyclovir
33
Q

whihc can effect liver enzymes?

A

valcyclobir

34
Q

whihc can be give topically? and side effects of topical?

A

acyclovir - pruritus and contact dermatitus

35
Q

whihc can be given systemically and side effects of systemic?

A

acyclovir - decreased hb, neutropenia, malasise, DVN, AKI, interistial nephritis

36
Q

side ffects of famicyclovir

A

headaches, nausea, fatigue, neutropenia and leukopenia

37
Q

side effects of valcyclovir

A

adbodminal pina, neuases, neutropenia, increased liver enzymes, headache, nsopharynitis, arthalgias, diarrhea and vomiting

38
Q

any drug reistsance for HSV and what do we do in this situraion?

A

acyclovir resistance for HIV patients who are immunocomprimised

  • mutation in DNA polymerase

we can use intralesional cidofovir

39
Q

Characteristics of RSV?

A

mild cold flu

40
Q

who does RSV affect most

A

affects young chldren infants most

most have had by second birthday

41
Q

RSV complications

A

penumonia or bornchitus

42
Q

TX

A

sym ptomatic

43
Q

severe tx

A

oxygen and IV fluids

44
Q

those most at risk?

A

young children with helath issue, immunocomprised and older people with lung and heart issues

45
Q

RSV commonly has what?

A

re-infection

Therapy: year 3 (14 decks)

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