Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Therapy: year 3 > Viral Hep > Flashcards

Viral Hep Flashcards

1
Q

Jaundice and increas serum ATL are part of whihc hep

A

acute

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

liver cirrhosis and complications of ESLD are part of whihc hep

A

chronic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

whihc hep has no treament?

A

a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

whihc hep can u be immunized for

A

hep a and b

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

whihc hep has transmission via percutanoues, sexual and perinatal

A

B and D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

whihc hep has a dna virus

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

whihc hep has insidious onset verusus sudden

A

B, C, D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

whihc hep has a chornic conponent/whihc has the largest chronic conpentent?

A

B, C, D

C (70-80%), B (9-10% inaudlts, 90% in children), D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

antigen and antibody for HAV

A

Antigen: hep a virus
Antibody: hep A antibody ( Anti-HAV)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

antigen and antibody for HBV

A

Antigen: HBsAb, HBcAg, HBeAg (surface core envelop)
Antibody: anti-HBs, anti-HBc (IgM- acute infection, IgG- chronic or recovery) , anti-HBe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

whihc antigen is not measure for hep b

A

core

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

antigen and antibody for HCV

A

Antigen: HCV

Antibody: anti-HCV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

following percutaneous needle injury what are you likely to get?

A

HIV, HCV, HBV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

whihc hep can be cured?

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Timeline of incubation, symptoms, infectivity and resoltion for hep A

A

Incubates: 28 days
Symptoms: children can be asymptomatic
infectivity: 2 weeks before symx
resolution: 2 months (up to 6 months)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

how does perinatal transmission occur and how should we treat it? What can mom do to prevnt it

A

mother is HBsAg positive at time of delivery

TX: HBIg and hep b vax to child within 12 hours of delivery and revax at 1 and 6 months ( reduces transimmison from 90% to 10%)

prvention: in third trimester mother can take nucleotide to reduce viremia (TDF)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

HBV post-exposure if HBsAg positive, known non-responder

A

IG and initiate vx series

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

HBV post-exposure if HBsAg positive, and antibody response unknown

A

test exposed person for anti-HHs, if inadequate response treat as non-responder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

clinical progression of Hep b

A

acute - chronic - cirrhosis (liver failure - decompensated, or liver cancer) - liver transplant and death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

HBsAg: negative
Anti-HBc: negative
Anti-HBs: negative

A

susceptible to virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

HBsAg: negative
Anti-HBc: Positive
Anti-HBs: positive

A

immune due to natural infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

HBsAg: negative
Anti-HBc: negative
Anti-HBs: positive

A

immune due to hep b vax

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

HBsAg: pos
Anti-HBc: pos
IgM anti-HBc: pos
Anti-HBs: negative

A

acutely infected

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

HBsAg: pos
Anti-HBc: pos
IgM anti-HBc: neg
Anti-HBs: negative

A

chronically infected

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

can hep b be cured?

A

not cured but controlled

26
Q

duration of hep infection?

A

over 6 months

27
Q

non-param for hep B and c

A
  • reudce weight if BMI >30
  • control sugars in DM
  • reduce hepatoxins (alcohol, acetaminophen, herbal products)
  • avoid NSADIS
  • reduce risk of transmission
    cover scrapes and cuts and bleach staidn
28
Q

hep b: if Alt is normal

A

no tx, unless signifianct disease suspected

29
Q

hep B : if alt is elevated and HBV DNA is 10 000- 10 000 000

A

consider pegiterferon or nuclos(t)ide analogues (entecavir, TDF, TAF), goals suppress HBe seroconversion

30
Q

hep B : if alt is fluctuates and HBV DNA is 10 000- 10 000 000

A

nuclos(t)ide analohgues (entecavir, TDF and TAF) lifelong

31
Q

hep B : if alt is elevated and HBV DNA is >100

A

nucleos(t)ide analog plus HBIg

32
Q

Interferon when best to use and for long long?

A

low effeicay when DNA is high and low AST, can be used when DNA is low however more serious effects

only works for 24-48 weeks, consider therpay for 16-48 weeks

33
Q

oral nucelosides inhibtiors used when, for how long, resistance and different types

A
  • longterm suppressive therapy
  • consider d/c after 12 months

Peginterferon : 180 mcg sq once weekly
entecavir : 0.5 mg Po daily: treamnt naive OR 1mg PO once daily : lamivudine resistance
TDF : 300 mg PO daily
TAF : 25 mg PO daily

34
Q

hep B if treament naive:

A

Tenofovir or entecavir ( high genetic barrier to resistance )

  • lamivudone - reisitance easier but can use entecavir then
35
Q

If hep B and HIV co-infection

A

TDF and 3TC (emtricitabine) - if we d/c this it can cause flare up and decompensation

36
Q

s/E /CI of Peginterferon

A

CI:
- major depressive order
- autoimmune
- cardiac
- decompensated cirrhosis
uncontrolled seizure disorder

37
Q

S/E entecavir

A

take on empty stomach

38
Q

TDF caution point

A

don’t use in renal insufficiency

39
Q

TAF caution point

A

can be used in patients with renal insufficiency until CrCl ,< 15 mL/min

40
Q

hep b monitoring

A

HBV DNA - q 3-6 months until undetable

ALT: q 3 mo nths

serology - surface, and envelope for q 6months on tx and d/c12-18 after treament

41
Q

hep C risk factors

A

sexual activity : MSM, STI

42
Q

Hep C testing

A

check if anti-HCV first then HCV RNA

43
Q

hep c clinical progression

A

acute - chronic - cirrhosis - HCC transplant and death

44
Q

what’s defined as a cure for hep C

A

undetecable viral load

45
Q

hep c tretament options

A

DAAs for 8-12 weeks

+/- ribavirin (added for treament expected or decomp liver)

46
Q

hep c tx for treatment experienced or decompensated cirrhosis

A

+/- ribavirin (added for treament expected or decomp liver)

47
Q

first line for hep c

A

alsways 2 DAAs

48
Q

the two DAA regimens

A

epclusa - sofosubuvir and velpatasvir
maviret - glecaprevir and pilbentasvir

49
Q

epclusa duration/ special diet?

A

12 weeks - no speial diets

50
Q

maviret duration/ special diet?

A

8 weeks - taken with food

51
Q

who is eleigible for simplfied tretament

A

adults with chornic hep c , who do not have cirrhosis, and no previous hep c trtemant

52
Q

epclusa - sofosbuvir/velpatatsvir drug class

A

NS5A inhib

53
Q

epclusa - sofosbuvir/velpatatsvir AE

A

fatigue and headache

54
Q

maviret - glecaprevir /pibrentasvir drug class

A

GLE: NS3/4a portetase inhibitor and pib:NS5A inhib

55
Q

maviret - glecaprevir /pibrentasvir AE

A

Fatigue, headche, diaarrhea, nausea, prurirtus

56
Q

DI with epclusa

A

Statins
PPI
H2RA
Anatcids
Amiodarone
HIV - Efavirenz, TDF

57
Q

DI with maviret

A

Statin
Ethinyl estradiol
PPI
HIV - Efavirenze, draunavir/lopinavir/ritonavir, rilpivirine

58
Q

HCV therpay caution points

A

HBV can be reactivated

59
Q

when should protease inhibtors be avoided?

A

such as maviret

  • ajundice, hepatic decomp, ascites, esophageal varicela hemorahge, hepatic encephalophathy
60
Q

moniotrng and lab values need to be checked before starting theroay

A

HCV RNA, LFT, SCr, CBC

HCV ressitance testing

HBV (HBsAg)

61
Q

efficacy tetsing

A

HCV RNA 12 weeks after completemnt of therpay

62
Q

If hep B coinfection what shoudl we do

A

give them hep b therpy fro 12 weeks

Therapy: year 3 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions