Cervical, Endometrial and Ovarian Cancer Flashcards
Most common histopathological type of cervical cancer
Squamous cell carcinoma
RF for cervical cancer
HPV, esp. 16 + 18
Late teens, early 20s
6 Sx of advanced cervical cancer
PV bleeding Postcoital bleeding Discharge Pelvic/ back pain Dyspareunia Obstructive uropathy
What has caused reduction in incidence of cervical cancer?
HPV vaccination
PAP smears- often asymptomatic
2 potential findings on examination in cervical cancer
Cervical mass or bleeding
Abnormal colposcopy: abnormal vascularity
Ix for cervical cancer
PAP Smear
HPV testing
Colposcopy
Biopsy
Tx for cervical cancer
Hysterectomy + lymphadenectomy
Chemoradiation: Cisplatin + Radiotherapy
Tx for metastatic cervical cancer
Combination chemotherapy- Cisplatin + Paclitaxel
+/- Bevacizumab
Fertility preserving surgery for cervical cancer
Cone biopsy or simple extra-fascial hysterectomy
Radical trachelectomy + lymphadenectomy
Most common histopathological type of endometrial cancer
Adenocarcinoma
RF for endometrial cancer
Overweight/ obese HRT PCOS FH Lynch synd PTEN tumor suppressor mutation (Cowdens)
Sx of endometrial cancer
post-menopausal vaginal bleeding (PVB)
Pelvic pain + palpable mass (Late stage)
Ix for endometrial cancer
Transvaginal US
Endometrial biopsy + histopathology
Tx for endometrial cancer
Total hysterectomy Bilateral salpingo-oophorectomy Lymphadenectomy Adjuvant vaginal brachytherapy Adjuvant Paclitaxel + Carboplatin Adjuvant external beam radiation
Tx for early stage endometrial cancer fertility preserving
Progestin: megestrol