Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

YR6 ONC > Cytotoxic agents > Flashcards

Cytotoxic agents Flashcards

1
Q

MOA of Cyclophosphamide

A

Alkylating agent- causes cross-linking in DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

3 adverse effects of Cyclophosphamide

A

Haemorrhagic cystitis
Myelosuppression
Transitional cell carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Name 2 cytotoxic antibodies

A

Bleomycin
Anthracyclines (e.g doxorubicin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

MOA of Bleomycin

A

Degrades preformed DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

1 adverse effect of Bleomycin

A

Lung fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

MOA of Anthracyclines e.g. Doxorubicin

A

Stabilizes DNA-topoisomerase II complex inhibits DNA + RNA synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

1 adverse effect of Anthracyclines e.g. Doxorubicin

A

Cardiomyopathy
Dose-dependent cardiotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

4 Antimetabolites

A

Methotrexate
Fluorouracil (5-FU)
6-Mercaptopurine
Cytarabine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

MOA of Methotrexate

A

Inhibits dihydrofolate reductase and thymidylate synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

4 adverse effects of Methotrexate

A

Myelosuppression
Mucositis
Liver fibrosis
Lung fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MOA of Fluorouracil

A

Pyrimidine analogue inducing cell cycle arrest and apoptosis by blocking thymidylate synthase (works during S phase)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

3 adverse effects of Fluorouracil

A

Myelosuppression
Mucositis
Dermatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

MOA of 6-Mercaptopurine

A

Purine analogue that is activated by HGPRTase, decreasing purine synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

1 adverse effect of 6-Mercaptopurine

A

Myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

MOA of Cytarabine

A

Pyrimidine antagonist.
Interferes with DNA synthesis specifically at the S-phase of the cell cycle + inhibits DNA polymerase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

2 adverse effects of Cytarabine

A

Myelosuppression
Ataxia

17
Q

MOA of Vincristine and vinblastine

A

Inhibits formation of microtubules

18
Q

2 adverse effects of Vincristine

A

Peripheral neuropathy (reversible)
Paralytic ileus

19
Q

1 adverse effect of Vinblastine

A

Myelosuppression

20
Q

MOA of Docetaxel

A

Prevents microtubule depolymerisation + disassembly, decreasing free tubulin

21
Q

1 adverse effect of Docetaxel

A

Neutropaenia

22
Q

MOA of Irinotecan

A

Topoisomerase inhibitor
Inhibits topoisomerase I which prevents relaxation of supercoiled DNA

23
Q

1 adverse effect of Irinotecan

A

Myelosuppression

24
Q

MOA of Cysplatin

A

Causes cross-linking in DNA

25
Q

3 adverse effects of Cysplatin

A

Ototoxicity
Peripheral neuropathy
Hypomagnesaemia

26
Q

MOA of hydroxyurea (hydroxycarbamide)

A

Inhibits ribonucleotide reductase, decreasing DNA synthesis

27
Q

1 adverse effect of hydroxyurea

A

Myelosuppression

YR6 ONC (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions