Adrenaline Flashcards

1
Q

What is the mechanism of action of adrenaline?

A

Alpha and beta adrenoceptor agonist

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2
Q

What are the beta1 effects of adrenaline?

A

Increases heart rate and contractility

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3
Q

What are the beta2 effects of adrenaline?

A

Causes peripheral vasodilatation

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4
Q

What are the alpha effects of adrenaline?

A

Causes vasoconstriction

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5
Q

What are the potential routes of delivery of adrenaline?

A
  • IM
  • IV
  • Nebuliser (in croup)
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6
Q

What are the indications for the use of adrenaline?

A
  • Anaphylaxis
  • Cardiopulmonary resuscitation
  • Bronchodilator in airway obstruction
  • Local vasoconstriction
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7
Q

When might the local vasoconstriction effects of adrenaline be useful?

A

To stop bleeding during endoscopy, or mixed with local anaesthetic drugs

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8
Q

What are the contraindications to the use of adrenaline for anaphylaxis or CPR?

A

None

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9
Q

When should adrenaline be used with caution?

A

Patients with IHD or other cardiovascular conditions

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10
Q

What are the contraindications to the use of adrenaline with local anaesthetic?

A

Should not be used in organs with end-artery blood supply, e.g. nose, external ear, digits, genitalia

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11
Q

Why should local anaesthetic mixed with adrenaline not be used in organs with end-artery supply?

A

Risk of tissue necrosis

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12
Q

What is the dose of adrenaline for use in CPR?

A

1mg IV 1 in 10,000 every 3-5 minutes

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13
Q

What is the dose of adrenaline for use in anaphylaxis?

A

500 mcg IM 1 in 1000

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14
Q

What monitoring should be done with adrenaline?

A

Monitor vital signs during and after treatment

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15
Q

What might adrenaline interact with?

A
  • Beta blockers

- MAOIs

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16
Q

What might happen if adrenaline is given with beta blockers?

A

Increased risk of hypertension

17
Q

What might happen if adrenaline is given with MAOIs?

A

Increased risk of hypertensive crisis

18
Q

What are the cardiovascular side effects of adrenaline?

A
  • Angina
  • MI
  • Palpitations
  • Tachycardia
  • Arrhythmias
  • Hypertension
  • Cold extremities
  • Pallor
19
Q

What are the respiratory side effects of adrenaline?

A
  • Dyspnoea

- Pulmonary oedema

20
Q

What are the GI side effects of adrenaline?

A
  • Nausea
  • Anorexia
  • Vomiting
  • Hypersalivation
21
Q

What are the genitourinary side effects of adrenaline?

A
  • Urinary retention

- Difficulty in micturition

22
Q

What are the CNS side effects of adrenaline?

A
  • Anxiety
  • Restlessness
  • Insomnia
  • Tremor
  • Sweating
  • Psychosis
23
Q

What are the endocrine side effects of adrenaline?

A
  • Hyperglycaemia
  • Metabolic acidosis
  • Hypokalaemia
24
Q

What are the ophthalmic side effects of adrenaline?

A
  • Angle-closure glaucoma

- Mydriasis

25
Q

What patient counselling is required if a patient is given an adrenaline auto-injector?

A
  • How to self administer

- Carry with them at all times

26
Q

What counselling is required regarding how to administer an adrenaline auto-injector?

A

Demonstrate IM administration to patient and ensure that they know how to use the device by asking them to demonstrate. Provide written information to patient to take home after consultation