GLP-1 Receptor Agonists Flashcards

1
Q

Give 2 examples of GLP-1 receptor agonists

A
  • Exenatide

- Liraglutide

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2
Q

What is the mechanism of action of GLP-1 receptor agonists?

A

Bind to, and activate, the GLP-1 receptor to increase insulin secretion, suppress glucagon secretion, and slow gastric emptying

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3
Q

What are the routes of delivery of GLP-1 receptor agonists?

A

SC

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4
Q

What are the indications for GLP-1 receptor agonists?

A

Type 2 diabetes

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5
Q

What are the contraindications to GLP-1 receptor agonists?

A
  • Diabetic ketoacidosis
  • Severe GI disease
  • Pregnancy and breastfeeding
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6
Q

When should GLP-1 receptor agonists be used with caution?

A
  • Elderly

- Renal impairment

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7
Q

What might GLP-1 receptor agonists interact with?

A
  • Warfarin
  • Other anti-diabetic drugs
  • Alcohol
  • Steroids
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8
Q

What might happen if GLP-1 receptor agonists are given with warfarin?

A

Increased anticoagulant effect

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9
Q

What might happen if GLP-1 receptor agonists are given with other anti-diabetic drugs, alcohol, or steroids?

A

Increased risk of hypoglycaemia

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10
Q

What monitoring is required with GLP-1 receptor agonists?

A
  • Monitor HbA1c and blood glucose every 6 months

- Monitor weight

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11
Q

What are the common side effects of GLP-1 receptor agonists?

A
  • GI upset

- Weight loss

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12
Q

What are the less common side effects of GLP-1 receptor agonists?

A
  • Severe pancreatitis
  • Hypoglycaemia
  • Anaphylactic reactions
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13
Q

What can potentially happen to the pancreas with GLP-1 receptor agonists?

A

Can become haemorrhagic and necrotising

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14
Q

What patient counselling is required with GLP-1 receptor agonists?

A
  • Not with food
  • Missed doses
  • Concomitant use of medications
  • When to seek help
  • Stop immediately in acute pancreatitis
  • Driving advice
  • Contraception
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15
Q

What should the patient be told about missed doses of GLP-1 receptor agonists?

A

If you have missed a dose, take the next dose as scheduled

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16
Q

What should the patient be told about concomitant use of medications with GLP-1 receptor agonists?

A

Some drugs, e.g. sulphonylureas, will require dose adjustment if used concomitantly

17
Q

What should the patient be told about when to seek help with GLP-1 receptor agonists?

A

If nausea, vomiting, or severe abdominal pain occurs

18
Q

What should the patient be told about acute pancreatitis with GLP-1 receptor agonists?

A

If it is suspected that acute pancreatitis has developed as a result of this drug, the drug must be stopped immediately in addition to seeking medical help

19
Q

What shouldWhat should the patient be told about contraception with GLP-1 receptor agonists?

A

Women of child-bearing age should use effective contraception during treatment with modified-release exenatide and for 12 weeks after discontinuation