PSMB - PHBP1

Question 1

Science that examines the inter-relationship of the physicochemical properties of the drug, the dosage form, and route of administration on the rate and extent of systemic drug absorption.

Answer 1

BIOPHARMACUETICS

Question 2

The study of the time course of drug movement in the body during absorption, distribution, and elimination.

Answer 2

PHARMACOKINETICS

Question 3

The study of the relation of drug concentration or amount at the site of action and its pharmacologic response.

Answer 3

PHARMACODYNAMICS

Question 4

Metabolism + Excretion

Answer 4

Elimination

Question 5

Distribution + Elimination

Answer 5

Disposition

Question 6

rate at which the solid drug enters into solution

Answer 6

DRUG DISSOLUTION

Question 7

rate limiting step in bioavailability

Answer 7

DRUG DISSOLUTION

Question 8

Equation involved in Drug Dissolution

Answer 8

Noyes-Whitney Equation

Question 9

PS and SA Relationship

Answer 9

↓ particle size = ↑ surface area = ↑ absorption

Question 10

Ratio solubility of the drug at equilibrium in a non-aqueous solvent

water phase compared with oil phase (octanol)

Answer 10

PARTITION COEFFECIENT

Question 11

Drugs that have relative relationship with octanol possess ____

Answer 11

positive integers

Question 12

Drugs that have relative relationship with water possess ____

Answer 12

negative integers

Question 13

Drugs that are weak electrolytes (acids or bases) exist in both an ionized form and a nonionized form in solution.

Answer 13

Extent of Ionization

Question 14

The choice of salt form for a drug depends on the desired physical, chemical, or pharmacologic properties.

Answer 14

Salt Formation

Question 15

ability of a drug to exist in more than one crystalline form

Answer 15

Polymorphism

Question 16

ability of a drug to exist as optically active stereoisomers or enantiomers

Answer 16

Chirality

Question 17

Enantiomer of Ibuprofen that is pharmacologically active

Answer 17

S-enantiomers

Question 18

Drugs may exist in hydrated, or solvated form or as an anhydrous molecule

Answer 18

Hydrates

Question 19

species formed by the reversible or irreversible association of two or more interacting molecules or ions

Answer 19

Complex

Question 20

complexes that typically involve a ring-like structure formed by the interaction between a partial ring of atoms and a metal

Answer 20

Chelates

Question 21

Metal in hemoglobin

Answer 21

IRON

Question 22

Metal in insulin

Answer 22

Zinc

Question 23

Metal in cyanocobalamin

Answer 23

Cobalt

Question 24

Delivery of active ingredient from a dosage form into solution

Answer 24

Liberation

Question 25

The process with the slowest rate constant in a system of simultaneous kinetic processes

Answer 25

Rate Limiting Step

Question 26

Serves as the rate limiting step in Liberation

Answer 26

Dissolution

Question 27

The process of uptake of the compound from the site of administration into the systemic circulation.

Answer 27

ABSOPRTION

Question 28

Bound to surface of skin or mucosa

Answer 28

Adsorption

Question 29

Drug reaches the deepest layer of the skin, yet does not reach the blood capillaries

Answer 29

Penetration

Question 30

Penetration and permeation

Answer 30

Sorption