GI 3 Flashcards
what is IDB?
a collective term of disorders of the GI tract characterized by persistent/recurring GI signs and histologic evidence of inflammation.
chronic immune mediated enteropathy of middle aged or older cats/dogs
***** loss of self tolerance and lack of protection, dysregulated inflammatory response, leading to malabsorption, maldigestion, clinical signs
IBD clinical signs?
chronic vomitting/diarrhea, abdominal discomfort, altered appetite, weight loss, borborygmi, flatulence
usually very progressive, can have GI urgency markers, and usually therapy fails
with IBD, what would the results be for folate and cobalamin
high folate, low cobalamin
true or false: IBD is a diagnosis of exclusion
true, rule out everything else
true or false: a GI biopsy will get you a definitive diagnosis for IBD
false. not enough to diagnose or to predict outcome! GI inflammation is present with IBD and with other GI insults so we can’t actually differentiate.
most commonly IBD is _____
lymphoplasmacytic
for chronic vomiting, think:
and rule out:
think: dietary intolerance, dietary allergy, helicobacter, bilious vomiting syndrome, ARD
rule out: addisons, hyperthyroidism, EPI, renal or pancreatic issues
for chronic diarrhea, think:
and rule out:
think: dietary intolerance, dietary allergy, fiber responsive colitis, gluten sensitive enteropathy
rule out: addisons, hyperthyroidism, EPI
if a patient has GI urgency markers, does not respond to therapy initially, consider:
IBD or a more serious enteropathy like lymphangiectasia
what is first line treatment for IBD?
hypoallergenic diet or novel protein
prednisone 2mg/kg/day
could add on cobalamin, probiotics, probiotics, abs for secondary ARD
true or false: severe IBD can lead to lymphangiectasia
true
what causes lymphangectasia and what are clinical signs?
immune system attacking the lacteals in the GI tract, they become dilated and protein is lost
diarrhea, weight loss, hyporexia, ascites
how to diagnose lymphangiectasia?
panhypoproteinemia and hypocholesterolemia
how to treat lymphangiectasia?
fat restriction, immunosuppression (pred 2mg/kg/day), cobalamin supplement
boxers with severe chronic large bowel diarrhea, think…
histiocytic ulcerative colitis: e coli in macrophages
treat with enrofloxacin
