Oral Viral Infections Flashcards

1
Q

8 stages of HSV replication?

A

Bind to cell

Enter cell

Release nuclear acids

Nuclear entry into nucleus

Gene expression

DNS replication

Packaging of viral proteins

Egress

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2
Q

Appropriate tests for viral infection?

A

Viral swab
- flocked swab
- placed in molecular sample solution

Blood sample
- EDTA

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3
Q

Clinical features of HSV?

A
  • gingivo stomatitis - along branch of trigeminal nerve and preceded by a prodrome period
  • herpes labialis
  • herpetic whitlow
  • Bell’s palsy
  • genital herpes
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4
Q

How test for HSV?

A

Vesicle / ulcer fluid - swab taken

  • sent for PCR testing and molecular sample media
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5
Q

Clinical features of HZV?

A

Vesicles appear along dermatome where virus has been dormant
- more common in V1

Shingles
- rash / vesicles on one side of the head or face
- can have muscle weakness
- intensely painful sometimes with paraesthesia too

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6
Q

Complications with HZV?

A

Post herpetic neuralgia
- shooting pain along dermatome

Secondary bacterial infection

Opthalmic zoster

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7
Q

Why is it important to treat shingles early?

A

Reduces severity and duration of pain and complications
- pain can mimic toothache

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8
Q

Clinical features of hand foot and mouth disease?

A

Fever, runny nose, sneezing, cough

Skin rash on hands and feet
Mouth blisters
Body and muscle aches

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9
Q

Tx of hand foot and mouth disease?

A

No specific medical tx
- symptomatic relief
- prevent dehydration
- emphasise role of hand hygiene to avoid transmission

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10
Q

Signs and symptoms of measles?

A

High fever, cough, runny nose - 7-14 days after exposure

2-3 days later
- koplik spots on inside of mouth - tiny white dots

3-5 days later
- rash begins of face and spreads down

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11
Q

Clinical features of mumps?

Caused by what?

A

Caused by paramyxovirus family

Headaches and fever
- swelling of the parotid glands unilaterally or bilaterally

Organ inflammation elsewhere

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12
Q

MOA aciclovir?

A

Broken down into aciclovir triphopshate

This competes for integration into Viral DNA
- then acts as a chain terminator

Thus inhibiting viral DNA replication

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