Ex. 3 - Asthma Drugs : LABA

Question 1

LABA MOA

Answer 1

Increase cAMP - bronchial smooth muscle relaxation and inhibit hypersensitivity mediators from mast cells (histamine and leukotrienes)

Question 2

LABAs

Answer 2

Aformoterol Tartrate (Brovana)
Formoterol (Perforomist)
Indacaterol (Arcapta Neohaler)
Olodaterol (Striverdi Respimat)
Selmeterol (Serevent)

Question 3

Aformoterol Tartrate

Answer 3

LABA
Brand: Brovana
Dosage form: Nebulizer solution
15mcg/2mL

Question 4

Aformoterol Tartrate
Dosing: 4-10, 5-11, Adult

Answer 4

Adult - COPD only

Question 5

Formoterol

Answer 5

LABA
Brand: Perforomist
Dosage form:
Nebulizer solution
20mcg/2mL

Question 6

Formoterol Dosing:

Answer 6

Adult - COPD only unless used in combo with ICS

Question 7

Indacaterol

Answer 7

LABA
Brand: Arcapta Neohaler
Dosage form:
Neohaler
75mcg/capsule

Question 8

Indacaterol Dosing:

Answer 8

Adult - COPD only

Question 9

Olodaterol

Answer 9

LABA
Brand: Striverdi Respimat
Dosage form:
Respimat 2.5 mcg/inhalation

Question 10

Olodaterol dosing:

Answer 10

Adult - COPD only

Question 11

Salmeterol

Answer 11

LABA
Brand: Serevent
Dosage form:
Diskus (50 mcg/blister)

Question 12

Salmeterol dosing:

Answer 12

Age 5-11
Adult

Question 13

LABA adverse effects

Answer 13

AE: tachycardia, headache, tremor, hypokalemia

Question 14

LABA Boxed warning
1:

Answer 14

for increased risk of asthma related
death for all monotherapy LABA use- should not be
used alone for asthma management

Question 15

LABA boxed warning 2:

Answer 15

For increasing hospitalizations in pediatric and adolescent patients

Question 16

LABA counseling:

Answer 16

Prolonged QT seen with intentional overdoses
* Not for acute symptoms
* May be helpful for exercise induce bronchospasm
* Formoterol and indacaterol capsules should not be
taken orally

Question 17

LABA Pediatric considerations

Answer 17

Most children <4 yo cannot provide sufficient inspiratory flow for adequate lung delivery with a DPI