Pitman et al Study (abnormal, bio) Flashcards
1
Q
Aim
A
To investigate whether PTSD symptoms could be reduced if those at risk ingest propranolol (a beta blocker) whitin 6 hourse of the traumatic event and continue drug treatment for 10 days.
2
Q
Procedure
A
- Approx 40 Emergency Department patients who just experienced a traumatic event
- First dose (40 mg) of propranolol or placebo recieved no longer than 6 hours after event
- Continued taking drug 4 times daily (also tolerated) for 10 days, followed 9-day taper period
- One and three months later, particpants returned for tests: Clinician Administered PTSD Scale (CAPS) and listening to a recording of themselves describing event while recording physiological data
3
Q
Findings
A
- When in the ER for the first time they had to make a video explaining the trauma (how they felt etc..)
- At one month: PTSD rate in placebo group was 30% and only 10% in propranolol group
- After three months: PTSD rate on placebo group was 13% and none in the propranolol groupo
- Placebo group also showed more physiological reaction whuile listening to their story (eg. increased heart rate, EMGs (skeletal muscles), Skin conductance)
- Supports the use of propranolol as a preventative treatment for PTSD and further research
- Supports PTSD diagnosis correlation with norepinephrine
4
Q
Strengths
A
Double-blind procedure
5
Q
Limitations
A
- Small sample - one outlier was excluded in findings from propranolol group (outlier experienced PTSD)
- Attrition (drop-out) rate different in propranolol group - ended with 10 in drug group, 15 in placebo group
- Possible noncompliance of taking medicine
- Possible differential in nurse attention
6
Q
Ethical Considerations
A
- Protection from harm
- Nurse was in regular contact with participants to monitor side efffects
- Participants were not prevented from seeking psychological treatment
- Many implications for dulling memories that could be required or useful later on
7
Q
Research Method
A
Experiment (lab or use)
