Respiratory - Sarcoidosis Flashcards

1
Q

What is sarcoidosis?

A

Chronic granulomatous disorder

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2
Q

What is a granuloma?

A

Inflammatory nodule full of macrophages

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3
Q

Who is affected by sarcoidosis?

A

20-40 or 60
Women
Black

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4
Q

What is the typical presenting complaint of sarcoidosis?

A

Dry cough
Shortness of breath
Nodules on their shins
Black, 20-40 years old

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5
Q

What are the skin features of sarcoidosis?

A

Erythema nodosum
Lupus pernio

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6
Q

What is erythema nodosum?

A

Nodules of inflamed subcutaneous fat on the shins

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7
Q

What is lupus pernio?

A

Specific to sarcoidosis

Raised purple skin lesions on cheeks and nose

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8
Q

As sarcoidosis affects multiple organs why is it a respiratory issue?

A

Lungs are affected most commonly

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9
Q

What happens to the lungs in sarcoidosis?

A

Mediastinal lymphadenopathy
Pulmonary fibrosis
Pulmonary nodules

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10
Q

What are the systemic symptoms of sarcoidosis?

A

Fever
Fatigue
Weight loss

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11
Q

What happens to the liver in sarcoidosis?

A

Liver nodules
Cirrhosis
Cholestasis

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12
Q

What happens to the eyes in sarcoidosis?

A

Uveitis
Conjunctivitis
Optic neuritis

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13
Q

What happens to the heart in sarcoidosis?

A

Bundle branch block
Heart block
Myocardial muscle involvement

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14
Q

What happens to the kidneys in sarcoidosis?

A

Kidney stones
Nephrocalcinosis
Interstitial nephritis

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15
Q

What is Lofgren’s syndrome?

A

Classic triad of symptoms in sarcoidosis
- Erythema nodosum
- Bilateral hilar lymphadenopathy
- Polyarthralgia

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16
Q

What blood tests are used to detect sarcoidosis?

A

Raised ACE
Raised serum calcium

17
Q

What imaging is used for sarcoidosis?

A

CXR- hilar lymphadenopathy
High-resolution CT- hilar lymphadenopathy and pulmonary nodules
MRI
PET scan

18
Q

What is present histologically with sarcoidosis?

A

Non-caseating granulomas with epithelioid cells

19
Q

How is sarcoidosis managed?

A

Conservative management
- Oral steroids, bisphosphonates to protect against osteoporosis
- Methotrexate
- Lung transplant

20
Q

What causes hypercalcaemia in sarcoidosis?

A

Granulomas
Uncontrolled synthesis of Vitamin D3 by macrophages