Disease Correlations: Glomerular Flashcards
Primary vs. Secondary
Primary: glomerulonephritis, immunologic, metabolic, hereditary
Secondary: systemic, diabetes, SLE, endocarditis
Morphological Changes
4
- Cellular proliferation
- Leukocyte infiltration
- Glomerular basement membrane thickening
- Hyalinization of glomeruli
Nephritic vs. Nephrotic
Nephritic
- More acute, blood, red cell casts, if more chronic then waxy/broad casts, hypertension
Nephrotic
- More chronic, lipids, OFB, fatty casts, low albumin, high cholesterol plasma, edema
Chronic Glomerulonephritis
what is it, leading cause of, correlations
Progessive destruction, hyalinized glomeruli, atrophied tubules
Leading cause of chronic renal failure
Correlations: gross hematuria, nephrotic, mental state, azotemia, oliguria
IgA Nephropathy
what is it, leading cause of, correlations
Berger’s Disease
Excess IgA accumulating in GBM
Correlation: asymptomatic hematuria, reccurent
Most common cause of chronic glomerulonephritis
Nephrotic Syndrome
Systemic and vascular
Systemic: SLE, HUS, diabetes, amyloidosis
Vascular: shock, low blood flow, microangiopathies
Membranous Glomerulonephritis
what is it, leading cause of, correlations
Thickening of GBM, immune mediated, Ig deposits
Major cause of nephrotic syndrome in adults
Correlations: large protein and hematuria, weight gain, edema, increased BP
Diabetic Nephropathy
what is it, leading cause of
Kidney blood vessel damaged, fluid accumulates, cell proliferation in capillary tuft
Vascular sclerosis
Leading cuase of end stage renal disease
Minimal Change Disease
what is it, leading cause of, correlations
Loose podocytes, idiopathic, T cell related
Most frequent cause of nephrotic syndrome in children
Corticosteroid therapy
Correlation: proteinuria, no blood, no increased BP
Rapidly Progressive Crescentic Glomerulonephritis
what is it, causes of it, correlation
Acute cellular proliferation
Cause: previous glomerular disease, systemic condition
Correlation: nephritic disease to renal failure
Acute Poststreptococcal Glomerulonephritis
After group A beta hemolytic strep
Good recovery
Correlation: edema, fatigue, Bp increase, oliguria, heamturia, sterile leukocyturia
Membranoproliferative Glomerulonephritis
What is it, correlation
Inflammation of capillary cells
Immunologic: IC buildup in GBM, lobing
- Slow and progressive, 50% lead to chronic renal failure
Correlation: nephritic to failure, oliguria, azotemia, BP up
Alport Syndrome
what is it, risk?, correlations
Abnormal collagen synthesis = GMB thickening
- More in males
- Genetic
Correlation: ear and eye problems, mild to nephrotic, increased transplant rejection
Goodpasture Syndrome
what is it, what does it cause, correlation
Anti GBM = destroy glomerular capillary
- Causes RPGN
Correlation: nephritic to renal failure, increased BP, respir. issues
Focal Segmental Glomerulonephritis
what is it
Scar tissue buildup
More mild, 10% nephrotic, idiopathic
