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PHYSIOLOGY III > L1: development of reproductive system > Flashcards

L1: development of reproductive system Flashcards

1
Q

sex cords form in response to …..

A

PGCs

primordial germ cells

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2
Q

once the genital ridge develops, what two ducts form

A

Mesonephric (Wolffian) and Paramesonephric (Mullerian) ducts

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3
Q

when PGCs reach the genital ridge, they establish as _______, precursors to gonads

A

Gonocytes

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4
Q

what chromosomes are necessary for the formation of testes

A

SRY (+XY)

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5
Q

A lack of SRY and TDF results in the formation of…

A

Oogonia (XX)
- granulosa cells
- thecal cells

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6
Q

during testicular development, cord cells and mesonephric cells become ____ cells

A

Sertoli

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7
Q

during male gonadal development, interstitial cells become ______ cells

A

Leydig
(source of testosterone)

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8
Q

in ovary development, cord cells become _____ cells

A

Granulosa

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9
Q

Leydig cells produce….

A

testosterone

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10
Q

Sertoli cells produce…

A

Anti-Mullerian Hormone (AMH)
- inhibits the development of Mullerian ducts

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11
Q

____________ (hint: hormone) targets the Wolffian ducts to become what 3 things

A

testosterone
- Epididymis
- Vas deferens
- seminal vesicles

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12
Q

hormone needed for theformation of external male genitalia(scrotum, penis, glans, prostate)

A

Dihydrotestosterone (DHT)

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13
Q

________ converts testosterone to dihydrotestosterone

A

5α reductase

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14
Q

the female fallopian tubes, uterus and vagina form from what

A

Mullerian ducts

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15
Q

in females, as the Mullerian ducts develop into female reproductive genitalia, ______ ducts regress

A

Wolffian

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16
Q

The absence of what 3 things allows for female genitalia to appear

A

No testosterone (Wolffian ducts regress)
No DHT
No AMH

17
Q

what is the role of the HPG axis in sexual development, puberty and maturation

A

functions during fetal life to promote the development of gonads

HPG is signaled by the hypothalamus to initiate puberty

18
Q

testes migrate through the ____ and _____ to reside in the scrotum

A

Body wall and Inguinal canal

19
Q

what are the 3 phases of testicular descent

A

Transabdominal phase
1. Descent from retroperitoneal position
2. growth of gubernaculum *IGF3
Inguinal-scrotal phase
3. shrinkage of gubernaculum back to scrotum and through the inguinal canal *testosterone

20
Q

T/F: cryptorchid testes can occur in males of any species

A

T

21
Q

the transabdominal phase of testicular descent is dependent on what molecule

A

IGF3

22
Q

the inguinal-scrotal phase of testicular descent is dependent on what

A

testosterone

PHYSIOLOGY III (31 decks)

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