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Derm1 > Ch. 1 - Glossary > Flashcards

Ch. 1 - Glossary Flashcards

1
Q

Acantholysis

A

Loss of cell-cell adhesion

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2
Q

Acanthosis

A

Increase in thickness of the epidermis. Can be regular or irregular (refers to level of the rete pegs).

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3
Q

Arborizing

A

Branching, often referring to rete or vasculature

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4
Q

Asteroid body

A

Collections of eosinophilic material seen in sporotrichosis, also star-shaped intracytoplasmic inclusions in granulomatous processes

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5
Q

Ballooning degeneration

A

Destruction of epidermis by dissolution of cell attachments and intracellular edema

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6
Q

Caterpillar body

A

Pale pink linear basement membrane material (type IV collagen) within epidermis, seen in porphyria cutanea tarda.

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7
Q

Civatte/colloid bodies

A

Pink, globular remnants of keratinocytes

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8
Q

Collagen entrapment

A

Collagen fibers (balls) surrounded by histiocytes/spindle cells.

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9
Q

Cornoid lamellae

A

45-degree parakeratosis in a column above a focus with diminished granular layer and underlying dyskeratotic cells.

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10
Q

Corps ronds/grains

A
  • Corps ronds = rounded nucleus with halo of pale dyskeratotic cytoplasm - Grain = dark blue flattened nucleus surrounded by minimal cytoplasm
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11
Q

Cowdry A body

A

Intranuclear pink inclusion of herpesvirus infection (AKA “Lipshutz body”

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12
Q

Cowdry B body

A

Intranuclear pink inclusions of adenovirus and poliovirus infections

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13
Q

Crust

A

Serum/fluid with inflammatory cells/debris in stratum corneum

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14
Q

Donovan body

A

Intracytoplasmic collections of bacteria seen in granuloma inguinale

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15
Q

Dutcher body

A

Intracytoplasmic pink masses of immunoglobulin that invaginate into plasma cell nuclei.

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16
Q

Effacement

A

Loss of normal rete pattern

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17
Q

Eosinophilic spongiosis

A

Spongiosis with eosinophils in the epidermis

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18
Q

Epidermolytic hyperkeratosis

A

Coarse, irregular hypergranulosis associated with disruption of cell membranes (associated with keratin 1 and 10 mutations)

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19
Q

Epidermotropism

A

Lymphocytes in epidermis with relative absence of spongiosis (usually reserved for mycosis fungoides)

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20
Q

Exocytosis

A

Lymphocytes in the epidermis with associated spongiosis (usually reserved for spongiotic dermatitis)

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21
Q

Festooning

A

Papillary dermis retains an undulating pattern (usually reserved for porphyria cutanea tarda)

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22
Q

Flame figure

A

Collagen encrusted with major basic protein from eosinophils

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23
Q

Follicular mucinosis

A

Alteration of hair sheath anatomy by pools of mucin

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24
Q

Grenz zone

A

Uninvolved area of dermis beneath the epidermis or adjacent to a hair follicle (border zone)

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25
Q

Guarnieri body

A

Eosinophilic inclusions of smallpox

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26
Q

Henderson-Paterson body

A

Intracytoplasmic oval, pink inclusions of molluscum infection

27
Q

Hyper/hypogranulosis

A

Increased/decreased granular layer

28
Q

Interface

A

Refers to the dermoepidermal junction

29
Q

Kamino body

A

Dull pink to amphophilic basement membrane material within the epidermis in a Spitz nevus

30
Q

Leishman-Donovan body

A

Intracytoplasmic collections of amastigotes in leishmaniasis

31
Q

Lentiginous epidermal hyperplasia

A

Elongated bulbous rete

32
Q

Lentigenous melanocytic growth pattern

A

Proliferation predominantly along the dermoepidermal junction

33
Q

Leukocytoclasia

A

Fragmentation of neutrophils (karyorrhexis)

34
Q

Lichenoid dermatitis

A

Interface dermatitis with destruction of the basal layer and Civatte body formation

35
Q

Lichenoid infiltrate

A

A band-like infiltrate of mostly lymphocytes at the dermoepidermal junction

36
Q

Medlar body

A

Brown, round structure resembling overlapping copper pennies. Divides by septation, resembling a hot-cross bun

37
Q

Metachromasia

A

Staining a different color from the stain itself

38
Q

Michaelis-Gutman body

A

Intra- and extracellular calcified, concentric circular structures, seen in malakoplakia

39
Q

Munro microabscess

A

Collection of neutrophils in the stratum corneum, as seen in psoriasis

40
Q

Necrobiosis

A

Pale-staining smudged necrotic collagen

41
Q

Negri body

A

Intraneuronal inclusion seen in rabies infection

42
Q

Orthokeratosis

A

Stratum corneum without retained nuclei (normal)

43
Q

Pagetoid cells

A

Large cells with abundant cytoplasm within the epidermis

44
Q

Pagetoid scatter

A

Buckshot scatter of atypical cells within the epidermis

45
Q

Palisading

A

Picket fence-like arrangement at the periphery

46
Q

Papillary mesenchymal body

A

Structure that resembles the whorl of plump mesenchymal cells normally present in the hair papilla (seen in trichoblastoma and trichoepithelioma)

47
Q

Papillomatosis

A

Exophytic finger-like projections

48
Q

Parakeratosis

A

Stratum corneum with retained nuclei

49
Q

Pigment incontinence

A

Melanin within dermal macrophages and free within the dermis

50
Q

Psammoma body

A

Extracellular laminated, calcified structures seen in meningioma, papillary thyroid carcinoma, ovarian carcinoma

51
Q

Pseudoepitheliomatous hyperplasia (PEH)

A

Prominent acanthosis of the adnexal epithelium and epidermis, mimics squamous cell carcinoma. Associated with trapping of elastic fibers

52
Q

Pseudohorn cyst

A

Keratin-filled cystic structure that results from cutting through invaginations of the stratum corneum (connects to surface, unlike horn cyst)

53
Q

Reticular degeneration

A

Destruction of epidermis with cell membranes remaining in a net-like pattern.

54
Q

Russell body

A

Intracytoplasmic pink collections of immunoglobulins in plasma cells, seen in rhinoscleroma and other plasmacytic lesions.

55
Q

Schaumann body

A

Laminated calcified structure seen in sarcoidosis

56
Q

Shadow cells

A

Cells with barely visible outlines of nuclei

57
Q

Spongiform pustule of Kogoj

A

Neutrophils in the stratum spinosum, associated with peripheral spongiosis (typical of psoriasis)

58
Q

Spongiosis

A

Intercellular edema in epidermis with stretching of cell-cell junctions

59
Q

Squamotization (squamatization)

A

Loss of cuboidal/columnar basal cells, with deepest layer replaced by polyhedral pink squamous cells

60
Q

Squamous eddies

A

Circular whorls of squamous cells

61
Q

Vacuolar change

A

Formation of clear spaces within the basal layer

62
Q

Verocay body

A

Structure composed of two nuclear palisades enclosing pink cytoplasmic processes, seen in Schwannoma

63
Q

Villus

A

Projection of papillary dermis covered by a layer of epidermal cells into a cavity.

Derm1 (30 decks)

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