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Derm1 > Ch. 15 - Disorders of skin appendages > Flashcards

Ch. 15 - Disorders of skin appendages Flashcards

1
Q

What conditions comprise the non-inflammatory alopecias?

A

Pattern alopecia (androgenetic balding)

Telogen effluvium

Trichotillomania

Tration alopecia

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2
Q

Pattern alopecia (androgenetic balding)

A

Miniaturization of follicular units with variability in diameter of follicles and decreased anagen:telogen ratio.

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3
Q

Telogen effluvium

(cause?)

A

Many telogen hairs. No miniaturization of pattern alopecia.

(interruption of anagen growth, eg febrile illness or crash diet)

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4
Q

Trichotillomania, traction alopecia

A

Empty anagen follicles, apoptotic keratinocytes in catagens, melanin casts, and trichomalacia.

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5
Q

What conditions comprise the inflammatory non-scarring alopecias?

A

Alopecia areata

Syphilitic alopecia

Alopecia mucinosa

Folliculotropic mycosis fungoides

Tinea capitis & Majogcchi’s fungal folliculitis

Acne vulgaris

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6
Q

Alopecia areata

A

Lymphocytes targeting melanocytes in the hair bulb (peribulbar infiltrate). Follicular miniaturization, melanin casts and eosinophils.

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7
Q

Syphilitic alopecia

A

Identical to alopecia areata (peribulbar inflammation), may contain plasma cells.

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8
Q

Alopecia mucinosa

A

Mucin within follicular epithelium and variable surrounding lymphoid infiltrate. Can be associated with mycosis fungoides.

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9
Q

Folliculotropic mycosis fungoides (cutaneous T-cell lymphoma)

A

Abnormal lymphocytes in the follicular epithelium (surrounded by white space). Papillary dermal fibrosis. CD7-.

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10
Q

Tinea capitis, Majocchi’s fungal folliculitis

A

Mixed inflammatory infiltrate. Fungal spores within or surrounding hair shaft.

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11
Q

Acne vulgaris

A

Infundibulum filled with laminated keratin and debris. Suppurative inflammation.

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12
Q

What conditions comprise the cicatricial alopecias?

A

Lupus erythematosus

Lichen planopilaris

Idiopathic pseudopelade

Central centrifugal cicatricial alopecia (CCCA)

Dissecting cellulitis

Folliculitis decalvans

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13
Q

Lupus erythematosus

A

Lymphoid infiltrate at the isthmus. Interface dermatitis. Hyperkeratosis. Perivascular/periadnexal infiltrate. Granular DIF.

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14
Q

Lichen planopilaris

A

Lymphoid infiltrate at the infundibulum. Lichenoid interface dermatitis. Civatte bodies. DIF with linear fibrin and cytoid bodies.

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15
Q

Idiopathic pseudopelade

A

Shrunken deep red “contracted” dermis with broad fibrous tract remnants. Thick elastic fibers.

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16
Q

Dissecting cellulitis

A

Clinically similar to nodulocystic acne, with deep dermal and subQ abscesses & granulation tissue.

17
Q

Folliculitis decalvans

A

Suppurative folliculitis with wedge-shaped scar. Resembles Staph folliculitis.

18
Q

Langerhans cell histiocytosis (histiocytosis X)

A

Perifollicular epithelioid histiocytes with edema & eosinophils.

Histiocytes stain with S100, CD1a, langerin. Birbeck granules.

19
Q

Chondrodermatitis nodularis helicis

A

Central ulcer with fibrin core and granulation tissue. Essentially a decubitus ulcer.

20
Q

Neutrophilic eccrine hidradenitis

A

Neutrophils within eccrine coil. Often noted during induction chemotherapy.

21
Q

Hidradenitis suppurativa

A

Suppurative folliculitis with abscess formation and sinus tracts with suppurative/granulomatous inflammation. Granulation tissue.

22
Q

Mucocele

A

Pooled mucin adjacent to minor salivary gland with variable granulomatous response.

23
Q
A

Pattern alopecia (androgenetic balding)

24
Q
A

Telogen effluvium

25
Q
A

Trichotillomania / traction alopecia

26
Q
A

Alopecia areata

27
Q
A

Syphilitic alopecia

28
Q
A

Alopecia mucinosa

29
Q
A

Folliculotropic mycosis fungoides

30
Q
A

Majocchi’s granuloma

31
Q
A

Lupus erythematosus

32
Q
A

Lichen planopilaris

33
Q
A

Idiopathic pseudopelade

34
Q
A

Folliculitis decalvans

35
Q
A

Langerhans cell histiocytosis (histiocytosis X)

36
Q
A

Chondrodermatitis nodularis helicis

37
Q
A

Neutrophilic eccrine hidradenitis

38
Q
A

Hidradenitis suppurativa

39
Q
A

Mucocele

Derm1 (30 decks)

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