Ch. 17 - Bacterial, spirochete, and protozoan infections Flashcards

1
Q

Impetigo

(cause?)

A

Neutrophilic crust. Chains or clusters of cocci.

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2
Q

What conditions present with neutrophils in the stratum corneum?

A

PTICSS:

Psoriasis

Tinea

Impetigo

Candida

Seborrheic dermatitis

Syphilis

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3
Q

Bullous impetigo

A

Subcorneal bulla with acantholysis in granular layer.

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4
Q

Suppurative folliculitis

(cause?)

A

Supurative inflammation in or around a follicle. Crust in stratum corneum.

(could be bacterial, fungal, chemical…)

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5
Q

Botryomycosis

A

Large staphylococcal grains in tissue (resembles mycetoma) with abscesses and sinus tracts.

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6
Q

Pitted keratolysis

A

Dell or pit in stratum corneum with rods/cocci. Located in acral skin.

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7
Q

Erythrasma

A

Rods forming vertical filaments in startum corneum. Variable inflammation.

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8
Q

Ecthyma gangrenosum

(cause?)

A

Necrosis of deep dermal vessels surrounded by amphophilic bacilli. No inflammatory infiltrate!

(pseudomonas sepsis)

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9
Q

Rhinoscleroma

(cause?)

A

Sheets of plasma cells and russell bodies. Mikulicz cells (resembles globi of leprosy).

(Klebsiella rhinoscleromatis)

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10
Q

Chancroid

A

Ulcer with necrosis/fibrin at surface. Granulation tissue with plasma cells below.

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11
Q

Granuloma inguinale

A

Pseudoepitheliomatous hyperplasia with neutrophilic abscesses. Donovan bodies (organisms within histiocytes).

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12
Q

Lepromatous leprosy

A

Perivascular lymphohistiocytic infiltrate with ample amphophilic cytoplasm. May form sheets with Grenz zone. Globi (amphophilic collections of mycobacteria).

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13
Q

Tuberculoid leprosy

A

Epithelioid granulomas“running east-west”. Rare organisms.

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14
Q

Histoid leprosy

A

Fibrous nodules and globi. Usually the result of long-acting dapsone.

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15
Q

Recite three types of leprosy reactions.

A

1 (reversal/downgrading): Increased immune infiltrate.

2 (erythema nodosum leprosum): Leukocytoclastic vasculitis and onion-skin fibrosis with globi.

3 (Lucio’s phenomenon): Massive load of organisms, inflammation, and thrombosis in arterioles.

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16
Q

Tuberculosis

A

Early suppurative reaction becoming granulomatous with central caseous necrosis.

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17
Q

Syphilitic chancre

A

Typical-appearing ulcer (zone of necrosis, underlying granulation tissue & plasma cells). Spirochetes on silver/IF.

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18
Q

Secondary syphliis

A

Vacuolar interface dermatitis with slender psoriasiform acanthosis. Endothelial swelling obliterates vessel lumen. Perivascular lymphocytes and histiocytes.

19
Q

Tertiary syphilis

A

Granulomas usually without visible organisms.

20
Q

Erythema migrans

A

Highly variable perivascular infiltrate (may contain plasma cells and/or eosinophils). Spirochetes in silver-stained sections.

(very non-specific…)

21
Q

Acrodermatitis chronica atrophicans

A

Dermal atrophy with sparse lymphohistiocytic band throughout dermis.

22
Q

Leishmaniasis

A

Granulomatous dermatitis with intracellular organisms at periphery of vacuoles.

23
Q

Acanthamoeba

A

Necrosis of deep vessels with organisms in vessel wall. Initially looks like large histiocytes.

24
Q
A

Impetigo

25
Q
A

Bullous impetigo

26
Q
A

Botryomycosis

27
Q
A

Pitted keratolysis

28
Q
A

Erythrasma

29
Q
A

Ecthyma gangrenosum

30
Q
A

Rhinoscleroma

31
Q
A

Granuloma inguinale (donovan body)

32
Q
A

Lepromatous leprosy

33
Q
A

Tuberculoid leprosy

34
Q
A

Histoid leprosy

35
Q
A

Reversal reaction (leprosy)

36
Q
A

Erythema nodosum leprosum

37
Q
A

Lucio’s phenomenon (leprosy)

38
Q
A

Tuberculosis

39
Q
A

Syphilitic chancre

40
Q
A

Secondary syphilis

41
Q
A

Tertiary syphilis

42
Q
A

Acrodermatitis chronica atrophicans

43
Q
A

Leishmaniasis

44
Q
A

Acanthamoebiasis