Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHRM 845 Therapeutics > Exam 3 - Lec 50 Migraines Ott > Flashcards

Exam 3 - Lec 50 Migraines Ott Flashcards

1
Q

migraine without aura (common) diagnostic criteria (4 things)

A

-at least 5 attacks
-headache lasting 4-72 hours
-unilateral location, pulsating, moderate/severe pain, aggravation by routine activity
-N/V, photophobia, phonophobia (fear of sound)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

migraine with aura (classic) diagnostic criteria (5 things)

A

-at least 2 attacks
-at least one fully reversible aura
-no aura lasting more than 60 min
-headache follows aura within 60 min
-aura symptoms: visual, sensory, speech/language, motor, brainstem, retinal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

4 migraine headache phases

A
  1. prodrome (hours or days before onset of headache)
  2. aura (before or during migraine, lasts < 60 min)
  3. migraine headache
  4. postdromal (may last several days after headache ended)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

a pt may experience euphoria, depression, irritability, food craving, constipation, neck stiffness, and yawning during which stage of a migraine headache?

a. prodrome
b. aura
c. migraine headache
d. postdromal

A

a. prodrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is a medication overuse headache?

A

rebound headaches from medication overuse more than two times per headache or two times per week chronically (associated with analgesics, ergots, triptans)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

medications that trigger migraines (5 of them)

A

-oral contraceptives
-hydralazine
-NTG
-nifedipine
-cocaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

analgesics should be limited for abortive tx of migraines for max of ___-___ days per week

A

2-3 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what medications are used for mild-moderate abortive tx of migraines? (2 of them)

a. triptans
b. NSAIDs
c. ergots
d. acetaminophen

A

b. NSAIDs
d. acetaminophen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what medications are used for moderate-severe abortive tx of migraines? (2 of them)

a. triptans
b. NSAIDs
c. ergots
d. acetaminophen

A

a. triptans
c. ergots

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

preventive tx for migraines is used when there are _____ or more attacks/month with disability at least _____ days/month

A

4; 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

NSAIDs such as ketoprofen, IV and IM ketorolac, and flurbiprofen are _____ line for abortive tx of migraines

A

second

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

triptans and NSAIDs such as aspirin, diclofenac, ibuprofen, and naproxen are _____ line for abortive tx of migraines

A

first

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

first line monotherapy for preventive tx of migraines (5 drugs in bold)

A

-valproate
-topiramate
-metoprolol
-propranolol
-frovatriptan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

second line monotherapy for preventive tx of migraines

a. amitriptyline
b. metoprolol
c. propranolol
d. topiramate
e. valproate

A

a. amitriptyline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Look at slide 11 for non-pharm therapy

A

Ok

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

theoretically, the use of a triptan with SSRI/SNRI can inc risk of which syndrome?

A

serotonin syndrome

17
Q

boxed warning for ergot alkaloids in abortive tx

A

serious/life-threatening peripheral ischemia

18
Q

ergot toxicity can occur if ergots are taken with which CYP inhibitors?

A

3A4 inhibitors

19
Q

3 CGPR receptor antagonists for abortive tx

A

rimegepant, ubrogepant, zavegepant (“gepant”s)

20
Q

what is the CI for CGPR receptor antagonists for abortive tx of migraines?

A

CI with strong 3A4 inhibitors

21
Q

which abortive drug for migraines should we avoid driving for at least 8 hours after dose?

a. butorphanol
b. lasmiditan
c. ubrogepant
d. NSAIDs

A

b. lasmiditan

22
Q

what should we monitor for pts on lasmiditan? (3 things)

A

LFTS, BP, HR (especially in CV pts)

23
Q

which drug is used as a rescue medication for abortive tx of migraines?

A

butorphanol nasal spray

24
Q

propranolol dose range/day for migraines

a. 80-240 mg/day
b. 100-200 mg/day
c. 25-150 mg/day

A

a. 80-240 mg/day

25
Q

metoprolol dose range/day for migraines

a. 80-240 mg/day
b. 100-200 mg/day
c. 25-150 mg/day

A

b. 100-200 mg/day

26
Q

amitriptyline dose range/day for migraines

a. 80-240 mg/day
b. 100-200 mg/day
c. 25-150 mg/day

A

c. 25-150 mg/day

27
Q

beta blockers CIs (2 of them)

A

-asthma
-Raynaud’s syndrome

28
Q

which CGRP antagonist has SE of nausea, constipation, and fatigue?

a. atogepant
b. rimegepant

A

a. atogepant

29
Q

which CGPR antagonist has SE of nausea, rash, and dyspnea?

a. atogepant
b. rimegepant

A

b. rimegepant

30
Q

valproate dose range/day for preventive tx of migraines

a. 500-1500 mg/day
b. 50-100 mg/day
c. 25-150 mg/day

A

a. 500-1500 mg/day

31
Q

topiramate dose range/day for preventive tx of migraines

a. 500-1500 mg/day
b. 50-100 mg/day
c. 25-150 mg/day

A

b. 50-100 mg/day

32
Q

valproate and topiramate are not recommended in which pts?

A

people of child-bearing age unless using contraception

33
Q

which natural product can be used for preventive therapy of migraines?

a. butterbur/petasites
b. riboflavin
c. coenzyme Q10
d. feverfew

A

a. butterbur/petasites

(150 mg/day)

34
Q

true or false: dihydroergotamine/ergotamine and valproate are CI in pregnancy for migraines

A

true

35
Q

which drug, if used in pregnancy for migraines, may cause fetal harm, and must be monitored for development of metabolic acidosis during and after pregnancy?

a. ergots
b. triptans
c. valproate
d. topiramate

A

d. topiramate

36
Q

which of the following are FDA-approved for children 12 and up as abortive therapy? SELECT ALL THAT APPLY

a. almotriptan
b. rizatriptan
c. zolmitriptan nasal spray
d. sumatriptan nasal spray
e. sumatriptan/naproxen
f. topiramate

A

a. almotriptan
c. zolmitriptan nasal spray
e. sumatriptan/naproxen

37
Q

which of the following are FDA-approved for children 6 and up as abortive therapy?

a. almotriptan
b. rizatriptan
c. zolmitriptan nasal spray
d. sumatriptan nasal spray
e. sumatriptan/naproxen
f. topiramate

A

b. rizatriptan

38
Q

which of the following is not FDA-approved in children?

a. almotriptan
b. rizatriptan
c. zolmitriptan nasal spray
d. sumatriptan nasal spray
e. sumatriptan/naproxen
f. topiramate

A

d. sumatriptan nasal spray

39
Q

which of the following is FDA-approved for children 12 and up for migraine prophylaxis?

a. almotriptan
b. rizatriptan
c. zolmitriptan nasal spray
d. sumatriptan nasal spray
e. sumatriptan/naproxen
f. topiramate

A

f. topiramate

PHRM 845 Therapeutics (34 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions